Drug Metabolism

Descripción

Notes from Doctors in Training
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Drug Metabolism
  1. Phase I
    1. Reactions
      1. Reduction
        1. Oxidation
          1. Hydrolysis
          2. Metabolites
            1. Slightly polar
              1. Water soluble
                1. Active
              2. Phase II
                1. Reactions
                  1. Acetylation
                    1. Methylation
                      1. Sulfation
                        1. Glucuronidation
                        2. Metabolites
                          1. Very polar
                            1. Inactive
                          2. Disulfiram-like reaction
                            1. Metronidazole
                              1. Certain cephalosporins
                                1. Procarbazine
                                  1. 1st generation sulfonylureas
                                  2. Zero order kinetics
                                    1. Phenytoin
                                      1. Ethanol
                                        1. Aspirin
                                        2. TCAs
                                          1. Imipramine
                                            1. Clomipramine
                                              1. Amitriptyline
                                                1. Nortriptyline
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