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Innate Immune Response

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Innate Immune Response
Harisson Kueh
Mapa Mental por Harisson Kueh, actualizado hace más de 1 año
Harisson Kueh
Creado por Harisson Kueh hace más de 8 años
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Innate Immune Response
  1. non-specific
    1. immune components preformed
      1. response magnitude
        1. similar during 1st and subsequent encounters
        2. No memory is stored
          1. 1st lines of Defence
            1. Physical barrier
              1. saliva
                1. antibacterial enzyme
                2. mucus linings
                  1. traps dirt and microbes
                3. Chemical barrier
                  1. skin
                    1. prevent entry of phatogents
                    2. tears
                      1. antibacterial enzyme
                      2. "good" gut bacteria
                        1. stop other harmful bacteria that taking over
                    3. 2nd lines of defence
                      1. fever
                        1. increase temperature above 37
                          1. change settings of hypothalamus
                            1. initiated by pyrogens
                            2. benefits
                              1. reduced iron availability
                                1. Inhibition of microbial multiplication
                                  1. increase metabolic reactions
                                2. inflammation
                                  1. redness
                                    1. heat
                                      1. pain
                                        1. oedema
                                          1. stages of inflammation
                                            1. tissue injury
                                              1. release of chemical signals such as histamine
                                              2. dilation and increased leakiness of local blood vessels
                                                1. migration of phagocytes to the area
                                                2. phagocytes
                                                  1. tissue heals
                                                3. release of cytokines
                                                  1. vasodilation
                                                  2. phagocytosis
                                                    1. macrophages
                                                      1. neutrophils
                                                        1. posses lysosome
                                                        2. Antimicrobial proteins
                                                          1. complement system
                                                            1. interferons
                                                              1. iron-binding protein
                                                                1. Antimicrobial peptides
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