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Cells of the Immune System
- Leukocytes (white blood cells)
- Small lymphocyte
- Production of antibodies (B cells) or cytotoxic
and helper functions (T cells)
- Production of antibodies (B cells) or cytotoxic
and helper functions (T cells)
- Natural killer cell
- Kills cells infected with
certain viruses
- Kills cells infected with
certain viruses
- Plasma cell
- Fully diferentiated form of B
cell that secreted antibodies
- Fully diferentiated form of B
cell that secreted antibodies
- Dendritic cell
- Activation of T cells and
initiation of adaptive
immune response
- Sessile dendritic cells
- Contact with external
environment e.g. skin
- Contact with external
environment e.g. skin
- Activation of T cells and
initiation of adaptive
immune response
- Neutrophil
- Phagocytosis and killing of
microorganisms
- Large range of receptors that mediate
recognition and phagocytosis
- Pattern recognition receptors (PRRs) that detect microbial associated
molecular patterns (MAMPs)
- Toll-like receptors (TLRs)
- NOD-like receptors (NLRs)
- RIG-I-like receptors (RLRs)
- Other cytosolic nucleic acid sensors
- C-type lectin
receptors (CLRs)
- Toll-like receptors (TLRs)
- Receptors that detect
signalling proteins e.g.
cytokines
- Peptidoglycan
recognition proteins
(PGRPs)
- Some are lymphocyte surface associated
- Some are intracellular
- Some are circulating
- Recognise, opsonise and some may be
directly antimicrobial
- Some are lymphocyte surface associated
- Pattern recognition receptors (PRRs) that detect microbial associated
molecular patterns (MAMPs)
- Can make alpha-defensins
- Pore forming peptide antibiotic
- Pore forming peptide antibiotic
- Phagocytosis and killing of
microorganisms
- Basopohil
- Unknown
- Unknown
- Eosinophil
- Killing of antibody-coated parasites through
release of granule contents
- Killing of antibody-coated parasites through
release of granule contents
- Mast cell
- Expulsion of parasites from body through
release of granules containing histamine and
other active agents
- Expulsion of parasites from body through
release of granules containing histamine and
other active agents
- Monocyte
- Circulating precursor cell to macrophage
- Circulating precursor cell to macrophage
- Macrophage
- Phagocytosis and killing of
microorganisms. Activation of T
cells and initiation of immune
response
- Motile mactrophages
- Patrol tissues acting as a first line
of defence
- Act as scavengers that rid the body of
worn-out cells and other debris
- Patrol tissues acting as a first line
of defence
- Subcategorised depending on
anatomical location
- Alveolar (lungs)
- Osteoclasts (bone)
- Microglia (brain)
- Kupffer cells (liver)
- Alveolar (lungs)
- Have receptors that can
talk to T-cells and
mediate adaptive
immunity
- Phagocytosis and killing of
microorganisms. Activation of T
cells and initiation of immune
response
- Small lymphocyte
- Lymphocyte
- Travel via the lymphatic system
- Lymph nodes act as sites of
communication between lymphocytes
- Travel via the lymphatic system
- Use confocal microscopy and staining
to study cells
- Green fluorescent protein (GFP)
- Green fluorescent protein (GFP)
- Recognition by lymphocyte
- Acid
- Toxic oxygen derivatives
- Peptides and proteins
- Enzymes
- Competitors
- Acid
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