550544
Descripción
Mapa Mental por Sophie Barrett, actualizado hace más de 1 año
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Creado por Sophie Barrett
hace casi 11 años
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Phospholipase C Pathway
- PLC is a membrane-assoiciated enzyme
- Activated by the G-protein that it is located close to.
- Activated by the G-protein that it is located close to.
- are 2 second messengers associated with this pathway:
- 1,2- diacylglycerol (DAG)
- inositol 1,4,5-triphosphate (IP3)
- Both of these can freely diffuse
in the cytosol
- IP3 opens Ca2+
channels in the
endoplasmic reticulum
membrane.
- causes a rise in intracellular Ca2+
- recruits Protein Kinase C (PKC) to the plasma membrane
- DAG activates PKC
- The activated membrane-assoiciated
kinase can phosphorylate cellular
enzymes and receptors (altering their
activity).
- The activated membrane-assoiciated
kinase can phosphorylate cellular
enzymes and receptors (altering their
activity).
- DAG activates PKC
- recruits Protein Kinase C (PKC) to the plasma membrane
- ER stores get depleted
- So, proteins assoiciated with the
IP3-gated Ca2+ channels open
store-operated Ca2+ channels in the
plasma membrane
- This allows influx of extracellular Ca2+
- Balanced :D
- Balanced :D
- This allows influx of extracellular Ca2+
- So, proteins assoiciated with the
IP3-gated Ca2+ channels open
store-operated Ca2+ channels in the
plasma membrane
- causes a rise in intracellular Ca2+
- Both of these can freely diffuse
in the cytosol
- both arise from the cleavage of
phosphatidyl inositol 4,5-biphosphate
(PIP2)
- 1,2- diacylglycerol (DAG)
- on activation, PLC cleaves a
membrane phospholipid called
PIP2, yielding 2 second
messengers:
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