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Actin & Cell Motility and Muscle Contraction
Descripción
(lecture 3) biosci 201 Mapa Mental sobre Actin & Cell Motility and Muscle Contraction, creado por nfnabilah_14 el 06/03/2014.
Sin etiquetas
biosci 201
lecture 3
Mapa Mental por
nfnabilah_14
, actualizado hace más de 1 año
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Creado por
nfnabilah_14
hace casi 11 años
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Resumen del Recurso
Actin & Cell Motility and Muscle Contraction
Cytoskeleton
Microtubules
Microfilaments
Intermediate filaments
Actin
Globular actin
Filament actin
The structure of actin and actin filaments
form bundles & network
Bundles
Networks
both B&N maintained by proteins that link them together
other proteins bind them to membranes
play in movement within cell
assembly/disassembly of filaments
trades for movement of motor protein
Branching of actin filaments and cell movement
Polymerisation of G-actin
Nucleation
Elongation
Steady state
preferential polymerisation at the (+) end
depolymerisation at the (-) end
Role of accessory protein in actin assembly
Profilin
recharge ADP-G-actin to ATP-G-actin to ATP-F-actin
Actin-related protein
Branching of actin daughter filaments
Gelsolin/cofilin
actin-severing proteins 'breaking' the actin filaments & capping the (+) end
Cell movement
Chemotaxis
Extension of lamellipodia
Adhesion of lamellipodia
Flow of cytosol
Retraction of the rear of the cell
happens because of actin polymerisation & depolymerisation
Motility of myosin motor proteins on actin filaments
Myosin head properties
ATP hydrolysis --> movement of myosin along an actin filament
hydrolysis of ATP generates 'power stroke' --> moves myosin
The contractile apparatus of muscle
Interaction of myosin and actin --> contraction of muscle
muscle cells has repeating arrays of filament bundles (sarcomere)
Actin filaments (thin)
Myosin filaments (thick)
The sliding filament model shows myosin pulls actin filaments towards the centre of sarcomere
Regulation of striated and smooth muscle contraction
Recursos multimedia adjuntos
lec_3.PNG (image/PNG)
lec_3_1.PNG (image/PNG)
lec_3_2.PNG (image/PNG)
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