772728
pharmacodynamics
- pharmacologic effect
- clinical response
- toxicity
- efficacy
- toxicity
- clinical response
- Target Sites
- Non-specific
interactions/non
receptor mediated
mechanism
- chemical rxn (non
receptor-mediated
mechanism
- antacid
- antacid
- surfactant (non recept.
med. rxn
- docusate sodium
- docusate sodium
- protein denaturation
(shrink, tighten mucus
membranes,
anti-inflammatory effects,
- astringents
- astringents
- osmotic effects
- alter the flow of
h2o b/t
compartments
- diuretics
- mannitol
- mannitol
- diuretics
- alter the flow of
h2o b/t
compartments
- selective toxicity
- chemotherapy compounds
- targets a select grp
of cells
- Lipids:
amphotericin B
- Nucleic Acids
- DNA
- daunorubicin, doxorubicin
- daunorubicin, doxorubicin
- RNA
- macrolides,
aminoglycosides,
fomivirsen,
amantidine
- macrolides,
aminoglycosides,
fomivirsen,
amantidine
- DNA
- Lipids:
amphotericin B
- targets a select grp
of cells
- chemotherapy compounds
- chemical rxn (non
receptor-mediated
mechanism
- Non-specific
interactions/non
receptor mediated
mechanism
- 4 levels for mechanism
of drug action
- Molecular
- targets regulatory
receptors
- targets regulatory
receptors
- cellular
- drug binds to receptor to
signaling pathway to start or
be inhibited
- drug binds to receptor to
signaling pathway to start or
be inhibited
- tissue
- affects fxn of
organ
- affects fxn of
organ
- system
- organ system fxn is
altered
- organ system fxn is
altered
- Molecular
- Ligand
- moecule or compd
that interacts with a
receptor
- Albuterol
- acts on Beta 2 receptor
which is activated, inducing
intracellular changes, PKA
phosphorylates enzymes to
inhibit muscle contraction,
cAMP keeps calcium in ER 
- acts on Beta 2 receptor
which is activated, inducing
intracellular changes, PKA
phosphorylates enzymes to
inhibit muscle contraction,
cAMP keeps calcium in ER 
- Albuterol
- selective
sub typing
- Based on
what the drug
binds to
- Based on
what the drug
binds to
- moecule or compd
that interacts with a
receptor
- Receptors
- Regions
- Extracellular
- intracellular
- to reach this type of
active site, a drug needs
to be lipophilic or small to
go thru the pores of the
cell membrane; can
diffuse through a
transporter
- to reach this type of
active site, a drug needs
to be lipophilic or small to
go thru the pores of the
cell membrane; can
diffuse through a
transporter
- transmembrane
- Extracellular
- Classification
- 2 overlapping systems
- Neurotransmitter
Receptors
- Gprotein
coupled
receptors
- acetylcholine,
serotonin
- acetylcholine,
serotonin
- ligand gated
ion channels
- Acetylcholine,
serotinin
- Acetylcholine,
serotinin
- Gprotein
coupled
receptors
- G-Protein Coupled
Receptors
- Neurotransmitter:
norepinephrine
- Peptides:
Glucagon
- Neurotransmitter:
norepinephrine
- Neurotransmitter
Receptors
- 2 overlapping systems
- Regions
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