Cell Signalling III

Description

Flashcards on Cell Signalling III, created by J yadonknow on 31/03/2018.
J yadonknow
Flashcards by J yadonknow, updated more than 1 year ago
J yadonknow
Created by J yadonknow over 6 years ago
5
0

Resource summary

Question Answer
Types of receptors (IGE IRNI) Ion channel-linked (ms) G protein coupled (s-hours) Enzyme-linked (s-hours) Intrinsic Enzyme activity Recruit enzymes from cytoplasm Nuclear Ionotropic ^ hours
Transporters Uniporter - substance 1 direction Symporter - 2 Δ sub. 1 direction Antiporter - 2 Δ sub. Δ directions
Ion channel-linked R Act as gates L-binding induces conf Δ, opening the gate
Pharma modding of ICL Channel blockers (physical block) Channel modulators (bind channel, enhance/inhibit opening.)
GPCRs Most common Trimeric G protein + coupled effector molecule 7 transmem helices
G protein binding site 3rd cytoplasmic loop Cytoplasmic C-terminal tail, sites available for +Pi
G proteins Guanine nucleotide binders
Forms of G proteins Monomeric i.e. Ras Trimeric (alpha,beta,gamma)
Trimeric Only alpha SU can bind Guanine Linked to PCM by lipid chain
GPCR binding (4) 1. Binding of L induces conf. Δ in R 2. + R binds to Gα SU 3. Binding induces conf. Δ in Gα 4. Bound GDP dissociates + is replaced by GTP. 5. Gα dissociates from Gβ/Gγ 6. L dissociated from R, Gα binds and + Effector. 7. Hydrolysis of GTP->GDP causes Gα to dissociate from Eff, re-associate with Gβ/Gγ. SWAPS GTP FOR GDP, DOESN'T CONVERT.
GPCR signal termination by R desensitisation Arrestin binds to +Pi form of GPCR Competes w/ G proteins for binding Promotes R interalisation via Clathrin-mediated endocytosis
Table of trimeric proteins
Learn glycogen metabolism like day before yah
cAMP level regulation using inhibitory hormone An example of GPCR signalling PGE1/Adenosine inhibits adenylyl cyclase GalphaI binds to adenylyl cyclase and inhibits it
Maybe learn AcCh here endothelial cells in BV to bring about smooth muscle relaxation
Show full summary Hide full summary

Similar

French Intermediate
PatrickNoonan
Elements, Compounds and Mixtures
silviaod119
GCSE PE - 1
lydia_ward
Cell Structure
daniel.praecox
Cognitive Psychology - Loftus and Palmer (1974)
Robyn Chamberlain
BIOLOGY B1 2
x_clairey_x
GCSE CHEMISTRY UNIT 2 STRUCTURE AND BONDING
mustafizk
Psychology subject map
Jake Pickup
Cell Transport
Elena Cade
The Strange Case of Dr. Jekyll and Mr. Hyde
K d
4. The Skeletal System - bones of the skull
t.whittingham