14047043
| Question | Answer |
| Trade names | - Diamicron- Glyade - Nidem (inc. MR) |
| Pharmaceutical class | Sulfonylurea |
| Indication | T2 DM |
| Action | Increases pancreatic insulin secretion May decrease insulin resistance. |
| Absorption & distribution | Easily absorbed in GIT - crosses placenta and enters breast milk |
| Metabolism & excretion | Extensively metabolised in the liver, metabolites excreted by the kidneys |
| Half-life | 10.4 hours |
| Contraindications & precaution | - T1 DM & Ketoacidosis - severe liver dysfunction - Pregnancy - Dose adjustment in renal impairment - Caution use during acute illness such as MI |
| Adverse reactions | ENDO: Hypoglycaemia Metabolic: weight gain GIT: discomfort, N & V SKIN: rash |
| Medication/diet interactions | use in combination with other antidiabetics can cause hypoglycaemia - alcohol can cause hypoglycaemia - corticosteroids, Beta2 agonists, thiazide diuretics & thyroid hormones can ^ BSL |
| Education | Advise PT to take with food Educate patient about diabetes (exercise, food) and consider referral to diabetes education Education about hypoglycaemia symptoms Instruct PT to drink glass of OJ if they notice signs of hypoglycaemia |
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