21878371
Description
Flashcards by Sam Adeyiga, updated more than 1 year ago
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Created by Sam Adeyiga
over 4 years ago
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| Question | Answer |
| Uroselective agents | 1. Tamsulosin 2. Alfazosin |
| Drugs that can worsen BPH *** Exam cases will include these 4 | 1. diuretics 2. decongestants 3. antihistamines 4. antidepressants |
| AUA snxs index for BPH 1. AUA < 8 (i.e. 0 - 7) = Mild LUTS 2. AUA =/> 8 = LUTS score >/= 8 w/o bordersome snxs 3. AUA =/> 8 = LUTS score >/= 8 w bordersome snxs 4. AUA 20 - 35 | 1. AUA < 8 = watchful waiting 2. UA =/> 8 = LUTS score >/= 8 w/o bordersome snxs = Watchful waiting 3. UA =/> 8 = LUTS score >/= 8 w/ bordersome snxs = Monotherapy with α1-adrenergic antagonists = 1st line therapy AUA 20 - 35 = Severe snxs |
| DRE minimum PSA minimum | 1. 40 gram 2. < 1.5 ng/mL |
| Trt Algorithm for BPH management Mild Snxs (AUA 0 - 7) | 1. Watchful waiting |
| Trt Algorithm for BPH management Mod snx + ED (AUA 8 - 19) | 1. A-adrenergic antagonist 2. PDE-5 3. Both |
| Trt Algorithm for BPH management Mod snx + small prostate and low PSA (AUA 8 - 19) | A-adrenergic antagonist |
| Trt Algorithm for BPH management Mod snx + large prostate and high PSA AUA 8 - 19 | 5-A-reductase Inhibitor + A-adrenergic antagonist |
| Trt Algorithm for BPH management Mod snx + irritative voiding snxs AUA 8 - 19 | 1. A-adrenergic antagonist + Anticholinergic 2. A-adrenergic antagonist + mirabegron |
| Trt Algorithm for BPH management Severe Snxs = Complications of BPH AUA = 20 - 35 DRE = > 40 g PSA = > 1.5 ng/dL | 1. Minimally invasive surgery or prostatectomy |
| α1-adrenergic antagonists drugs ("Zosins") | 1. Alfuzosin (Uroxatral®) 2. Doxazosin (Cardura®) 2-6 weeks *** 3. Doxazosin (Cardura-XL®) 4. Tamsulosin (Flomax®) 5. Terazosin (Hytrin®) 2-6 weeks *** 6. Silodosin (Rapaflo®) |
| 5α-Reductase Inhibitors | 1. Dutasteride (Avodart®) 2. Finasteride (Proscar®) |
| Combination 5α-Reductase Inhibitor/α-Adrenergic Receptor Antagonist | Dutasteride and Tamsulosin (Jalyn®) |
| phosphodiesterase inhibitors (PDE-5 inhibitors) | 1. tadalafil (Cialis®), 2. vardenafil (Levitra®) 3. sildenafil (Viagra®) |
| Antimuscarinic agents | 1. mirabegron 2. tolterodine 3. oxybutynin 4. trospium 5. solifenacin 6. darifenacin 7. fesoterodine |
| What do you give a patients with an enlarged prostate of greater than 40 grams and/or a PSA elevated to > 1.5 ng/mL? | Combined therapy of 5-A-reductase Inhibitor + A-adrenergic antagonist |
| TURP | 1. reduction in AUA-SI score of 15 points |
| Open prostatectomy | 1. typically reserved for males with prostate size > 80 grams |
| TUIP | 1. a surgical option in men with a prostate size of < 30 grams |
| TUNA | 1. TUNA uses radiofrequency waves to heat the prostate causing necrosis of the tissue. |
| TUMT | 1. delivers heat to the prostate via a urethra catheter, causing necrosis of prostate tissue. |
| Lifestyle Modification / Behavioral changes for BPH pts. (1) | Fluid restriction (1500-2000 mL/day), or fluid restriction at bedtime or prior to times when symptoms are bothersome (e.g., long trips or in public) |
| Lifestyle Modification / Behavioral changes for BPH pts. (2) | 1. Avoidance of caffeinated beverages, alcoholic beverages, and spicy foods 2. Replacement of large volume alcoholic beverages with small volume alcoholic beverages |
| Lifestyle Modification / Behavioral changes for BPH pts. (3) *** | Avoidance or adjustment of certain medications e.g., 1. diuretics 2. decongestants 3. antihistamines 4. antidepressants |
| Lifestyle Modification / Behavioral changes for BPH pts. (4) | 1. Timed or scheduled voiding (bladder retraining) 2. Pelvic floor exercises 3. Avoidance of constipation 4. Use of frequency and volume charts (diary) to monitor symptoms and for progression of symptoms |
| What is the trt option in men with VEGF and hematuria due to prostatic bleeding | 1. 5α-Reductase Inhibitor 2. Finasteride |
| 3rd Gen 5α-Reductase Inhibitors Selective α1 Inhibitors | 1. Silodosin 2.Tamsulosin |
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