5282057
Description
Flashcards by Anuarruddin Azmilumur, updated more than 1 year ago
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Created by Anuarruddin Azmilumur
over 8 years ago
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| Question | Answer |
| Adaptive Immune Response | - Specific - Fully activated only after infections - Response magnitude higher in the second infections - Memory stored |
| Development of Lymphocytes | T cells B cells |
| Antigen-independent maturation sites | T cells in thymus B cells in bone marrow |
| Function of surface markers or receptors | i. Bind to receptors on other cells ii. Bind to antigen iii. Transmit and receive messages |
| Common receptor molecules | i. Major histocompability complex (MHC) ii. Cluster of differentiation (CD) iii. Antigen-specific receptors |
| Three class of MHC | i. Class I - expressed on all nucleated cells ii. Class II - on APCs ; dendritic cell, macrophages, B cell iii. Class III - on protein associated with complement system |
| CD molecules sites of binding | |
| Antigen-specific receptors & Clonal deletion | |
| Presentation of antigen | Antigenicity based on: i. Size ii. Complexity iii. Foreignness |
| Role of antigen-presenting cell | |
| Receptors on T cell and B cell | T cell receptor (TCR) - supported by co-receptor such as CD4 CD8 B cell - immunoglobulins or antibody Class - IgG IgA IgM IgE IgD |
| T cell activation | |
| Function of T cell differentiations | T helper cell - stimulate or activate other cells, including macrophages, B cell, cytotoxic cell Memory T cell - store immunological memory Regulatory T cell - regulate other cells to prevent excessive inflammation & autoimmune Cytotoxic cell - infected host cell, cancerous host cell, foreign cells. involve secretion of granzyme & perforins |
| B cell activation | |
| Role of B cell differentiation | Memory cell - store immunological memory Regulatory B cell - regulate to prevent excessive inflammation & autoimmune Plasma B cell - launch antibodies (opsonisation, neutralisation, agglutination, ) |
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