Created by gina_evans0312
almost 11 years ago
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Question | Answer |
Source of Histamine | Histadine |
Sources of Histamine | Red granules of Mast cells, or Endochromaffin cells/histaminergic neurons |
No of Histaminergic receptors | 4 |
Receptors worked on by anti-histaminics | 1 & 2 |
Receptors found on immune cells | 1, 2 & 4 |
H1- Location | Smooth muscle of the respiratory tract & on vascular endothelial cells |
H1- Role | Sooth Muscle contraction, vasodilation and immune modulation |
H1- Effects | Breathless/wheezing & redness/itching |
H2- Location | Gastroparietal & heart cells |
H2- Effects | Inc. acid production & inc heart contraction |
H3- Location | Part of the CNS |
H3- Role | Sleep cycle & cognition |
Histamine receptors are _ coupled | G-protein |
Net result of histamine receptor stimulation | Inc Ca2+, Adenylate Cyclase and MAPK stimulation |
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