Antibiotics W/ Organisms

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Antibiotics working on which organisms according to Master The Boards for Step 2 CK
Ahmed Radwan9332
Flashcards by Ahmed Radwan9332, updated more than 1 year ago
Ahmed Radwan9332
Created by Ahmed Radwan9332 over 8 years ago
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Question Answer
Penicillin (G, VK, benzathine) work on which organisms. viridans group strept. + Streptococcus pyrogens + oral anaerobes + syphilis + Leptospira.
Ampicillin & amoxicillin work on which organisms Same as penicillins + Lyme disease, HELPS (H. influenza , E. coli, Listeria, Proteus, Salmonella)
Penicillins are best initial therapy in? - Otitis media - Dental infections. - Endocarditis prophylaxis. - Lyme limited to rash, joint, or 7th cranial nerve. - UTI in pregnants. - Listeria monocytogenes. - Enterococcal infections.
Penicillinase - resistant penicillins (oxacillin, cloxacillin, dicloxacillin, nafcillin) used to treat ? - Skin infections (Cellulitis, impetigo, erysipelas) - Endocarditis. - Meningitis. - Bacteremia from staph. - Osteomyelitis and septic arthritis only when proven sensitive.
When is Methicillin the right answer? Never
(Pipracillin, ticarcillin, azolocillin, mezlocillin) are best initial therapy for? - Cholecystitis. - Ascending cholangitis. - Pyelonephritis. - Bacteremia. - Hospital acquired and ventilator associated pneumonia. - Neutropenia and fever.
What is the only cephalosporin that will cover MRSA? Ceftaroline
All cephalosporins in all classes cover? - Group A, B, C strept. - Viridans strept. - E. coli. - Klebsiella. - Proteus mirabilis.
First Gen cephalosporin examples? Cefazolin, cefadroxyl, cepharadrine, cephalexin.
First gen cephalosporin used to treat ? - Staph. - Strept. ( except enterococcus) - E. coli. - osteomyelitis. - septic arthritis. - cellulitis.
Only cephalosporin that cover anaerobes are? Cefotetan + cefoxitin ( both are 2nd gen)
2nd gen cephalosporin examples. Cefotetan cefoxitin cefuroxime. laracarbef cefaclor cefprozil
Best initial therapy for Pelvic inflammatory disease? cefotetan or cefoxitin combined with doxycyclin.
Dangerous side effect of cefotetan and cefoxitin. - increase risk of bleeding. - disfulfiram like reaction with alcohol.
3rd gen cephalosporin examples. ceftriaxone, cefotaxime, ceftazidime.
Ceftriaxone used to treat. - 1st line for pneumococcus ( even when partially insensistive) - Meningitis. - community acquired pneumonia( in combination with macrolides) - Gonorrhea. - Lyme involving heart or brain.
why avoid ceftriaxone in neonates? because of impaired biliary metabolism. ( used cefotaxime)
Cefepime used for? - neutropenia + fever. - Ventilator associated pneumonia.
What is used with neutropenic fever? - Pipracillin with tazobactam. - Carbapenems. Cefepime.
Examples of carbapenems. Imipenem. Meropenem. Doripenem. Entrapenem ( different in NOT covering Pseudomonas)
What is Aztreonam? Only drug in the monobactams and used to treat Pseudomonas.
Best therapy for community acquired pneumonia? Fluroquinolones
The only Quinolone used for diverticulitis and GI infection as single agent is? Moxifloxacin. ( Does not need metronidazol)
Side effects of Quinolones - Bone growth abnormality in children and pregnant. - Tendonitis and achillis tendon rupture.
Uses of Fluoroquinolones? - Gram - ve bacilli including pseudomonas. - Cipro for cystitis and pyelonephritis. - Community aquired pneumonia.
Uses of Aminoglycosides. (Gentamicin, Tobramycin, Amikacin) - Gram -ve bacilli (bowl, urine, bactremia) - Synegestic with betalactam AB for enterococci and staph.
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