Created by gina_evans0312
almost 11 years ago
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Question | Answer |
Isotypes | Ig classes based on 5 H chain variations |
L Chain Variations | Kappa or Lambda (not both) |
Functional Changes In Isotypes | Different Isotypes have different functions |
Different Isotypes | Have different structures and bind to different receptors |
IgG (Most Common)- Function | Fixes compliment and promotes opsonisation |
IgG- Placenta Crossing | Only Ig to do so |
IgA Secretion | Done by B cells (most common in external secretions) |
Serum IgA | Monomer |
Secreted IgA | Dimer |
IgA Secretion Requirements | IgA, and IgAR, a receptor found in the inner lining of epithelial cells |
IgA Transcytosis | The IgA and IgAR are passed through the epithelial cell |
IgA Exocytosis | The IgA and the IgAR remain bound (though it's partially degraded) |
IgE | Cause activation of allergic response- recognised by Mast cells |
Role of IgM | Increases antigen avidity & is most effective at fixing compliemnt |
IgM Structure | Forms a pentamer held by disulphide bonds |
IgM & IgD | Form the BCR |
Avidity | Overall strength of Ig-Ag interaction |
B Cell Recognition | Can recognise any type of antigen (lipid/peptide/glycoprotein) |
T-Cell Recognition | Only recognise small, processed peptides |
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