Lymphoid organs and tissues

Description

Immunopathology Flashcards on Lymphoid organs and tissues, created by lumen7 on 30/04/2013.
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Flashcards by lumen7, updated more than 1 year ago
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Created by lumen7 over 11 years ago
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Resource summary

Question Answer
Recognition Need to see wide range of foreign organisms/objects;  Variety far exceeds capacity;  Process required which can detect everything and then focus after initial recognition
Specificity Must be able to differentiate self from non-self;  Must respond to non-self but not self;  Low specificity at outset aids recognition of a wide range of antigens;  Increasing specificity as response progresses concentrates effort where needed and avoids unnecessary damage;  Specific responses can be ‘remembered’ in case of future infection
Response Rapid response ensures that attack is countered as soon as possible and before infection can spread; Different assaults require different response; Much more difficult to avoid a range of responses than a single one; Response must be strong enough to eliminate threat but with minimal co-lateral damage;  Response needs to be co-ordinated; Communication is important;  Duplication is a waste of effort, therefore aspects of the innate response are recruited to the adaptive response
Primary lymphoid organs Bone marrow and thymus  Sites of immune cell development and maturation
Secondary lymphoid organs Lymph nodes, spleen and mucosal lymphoid tissue  Sites of antigen presentation that initiate the acquired immune response  Act as filters to capture antigen and present it to T cells and B cells  Lymph nodes in the lymphatic circulation  Spleen in the cardiovascular circulation  Mucosal immune system for antigen crossing mucosal surfaces.
All blood cells and platelets develop in the bone marrow from pleuripotent stem cells
Lymphocyte development is sometimes referred to as lymphopoiesis
B cell development is completed within the bone marrow
T cells migrate to the thymus to complete their development, thus they are thymic dependent
B cell development is marked by different stages of immunoglobulin gene rearrangement and expression
T cell development is marked by different stages of immunoglobulin gene rearrangement and expression in the thymus
Thymic activity is greatest in early life
B cells are generated continually throughout life
Lymph nodes – respond to antigens in the lymph
Spleen – respond to antigens in the blood
Mucosal associated lymphoid tissue – respond to antigens crossing mucosal surfaces
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