6838317
Description
Flashcards by Dan McArthur, updated more than 1 year ago
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Created by Dan McArthur
about 8 years ago
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| Question | Answer |
| What are the Catecholamines? | Noradrenaline Adrenaline Dopamine |
| Catecholamine Synthesis: (5) Substrates (3) Enzymes | |
| Cocaine | Blocks catecholamine reuptake channels Allows Noradrenaline to remain in the synapse for prolonged period |
| MAO-Inhibitors Monoamine Oxidase Inhibitors | Inhibits the degradation of Noradrenaline so that increased levels remain in the neuron |
| Sympathomimetics | Drugs that mimick Noradrenaline (have similar structure) and so compete to bind to MAO, displacing NA and maintaining higher levels of NA. e.g. Amphetamine, Ephidrine, Tyramine Isoprenaline, Phenylephrine |
| Alpha 1 Receptors | Post junctional Gq Protein Causes increase in IP3 and DAG Constriction of Vascular Smooth Muscle Vasoconstriction |
| Phenylephrine | Selective Alpha Agonist |
| Phentolamine | Selective Alpha Receptor Antagonist |
| Isoprenaline | Selective Beta Receptor Agonist |
| Propranolol | Selective Beta Receptor Antagonist |
| Prazosin | Selective Alpha 2 Receptor Antagonist (Hypertension) |
| Clonidine | Selective Alpha 2 Agonist |
| Alpha 1 Receptors (1) Location (1) G Protein (1) Associated Protein (1) 2nd Messengers (1) Effect | Located on Vascular Smooth Muscle Gq Protein Phospholipase C Increase in IP3 and DAG Causes Vasoconstriction |
| Alpha 2 Receptors (1) Location (1) G Protein (1) Associated Protein (1) 2nd Messengers (1) Effect | Located on Prejunctional Neurons But Also Gut and GIT Gi (Inhibitory) Adenylate Cyclase Decrease in cAMP Decrease in NA release (Neg Feed) |
| Beta 1 Receptors (1) Location (1) Effect | Located on the Heart Causes stimulation Increase in Contractile Force and Rate |
| Beta 2 Receptors (1) Location (1) Effect | Located on the Smooth Muscle of Bronchi Blood Vessels of Heart, Liver, Sk.Muscle Has an inhibitory effect Bronchodilation Vasodilation Responds to Adrenaline |
| Beta Receptors (1) G Protein (1) Associated Protein (1) 2nd Messengers | Gs Protein Adenylate Cyclase Increase in cAMP Either Inhibitory or Stimulatory Effect Depending on Location, Type of Receptor |
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