712276
Description
Flashcards by gina_evans0312, updated more than 1 year ago
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Created by gina_evans0312
over 10 years ago
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| Question | Answer |
| Disease Caused | Tetanus |
| Source of Bacteria | Dust/soil in wounds |
| Aerobic or Anaerobic? | All Clostridium are Obligate Anaerobes |
| Tetanospasmin (Exotoxin) Structure | 2 heavy chains, 1 light chain |
| Tetanospasmin (Exotoxin) Role of Structure | 2 heavy chains- bind to nerve terminal, light chain causes effect |
| Tetanospasmin (Exotoxin) Binding | To gangliosidase Receptors, which endocytose it and release it in the CNS |
| Tetanospasmin (Exotoxin) Inhibitory Neurones | Taken up by 'muscle relaxing' neurones, where light chain binds snare protein Synaptoprenin |
| Tetanospasmin (Exotoxin) Effect | Neurotransmitter cannot be release, muscles cannot relax |
| Symptoms | Lockjaw, arched spin, bent limbs, respiratory spasm |
| Vaccine | Directed against tetanospasmin |
| Atoxoid | Inactive toxin that triggers the immune system (found in vaccine) |
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