720999
Description
Flashcards by gina_evans0312, updated more than 1 year ago
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Created by gina_evans0312
over 10 years ago
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| Question | Answer |
| Drug Induced | In susceptable individuals |
| Symptom | Haemolytic Anaemia |
| G-6-PDH is part of... | Pentose Phosphate pathway |
| Reaction | Glucose-6-P + NADP --> NADPH + P-Gluconolactine |
| Role of Pathway | To reduce glutathiones, which keep Hb and RBC membrane proteins in their reduced form |
| Peroxides | Reduces peroxides |
| Effect of Antimalarials | Contain peroxides which cannot be reduced, Hb becomes oxidised to Methemoglobin, and the spleen destroys the RBCs |
| Favism | Mediterranean form of deficiency- occurs when Fava beans are eaten |
| Fava Beans | Also contain peroxides, same effects |
| Protection | May confer protection from Fulciparum malaria, which rely on glutathiones at one point |
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