Flashcards
Fatty Acid Synthesis
Cards in this deck (26)
- 1In what kind of pathways are NADPH and NADH primarly used?NADPH - biosynthesis pathways
NADH - energy yielding pathways - 2Aspirin inhibits the production of various molecules from arachidonic acid. Which of the following does it NOT inhibit: prostaglandins, thromboxanes, prostacyclin, leukotines?Leukotines
- 3What is the purpose of arachidonic acid?To provide building blocks for various other molecules such as prostglandins, thromboxanes.
- 4Give an example of an eicosanoid hormone and what is it derived from.Arachidonic acid - derived from linolenic acid
- 5What are eicosanoid hormones?They are hormones derived from long chain FAs
- 6How does the body get fatty acid chains with more than 9 double bonds? What are 2 examples?By consuming them in our diet. Linolenic and linoleic acid.
- 7What is the maximum number of double bonds that can be produced in the body (in a fatty acid)?9
- 8What enzyme is used to make unsaturated fatty acids?Desaturase enzyme
- 9How can fatty acids longer than 16C be made?By further condensation reactions using enzymes on the SER in the cell and adding malonyl CoA to increase the chain by 2C each time.
- 10What is the longest FA chain that can be produced from this pathway?16 carbon chain
- 11Why does the fatty acid synthesis pathway continue?It continues to build up longer chain molecules.
- 12What kind of reaction is the final reaction in fatty acid synthesis?Reduction reaction (redox)
- 13What kind of reaction is the third reaction in fatty acid synthesis? What is the purpose of it?It is a dehydration reaction. It prepares the molecule for the next step.
- 14What are the four reactions in the fatty acid synthesis pathway?Condensation -> reduction -> dehydration -> reducion
*Opposite to B-oxidation - 15What electron carrier is used in the second reaction in fatty acid synthesis?NADPH.
- 16What kind of reaction is the first reaction in fatty acid synthesis (after ACP has been added)? What is its purpose, what powers it and what size molecule is produced?Condensation reaction and decarboxylation. It increases chain length to a 4C molecule. It is powered by decarboxylation of malonyl.
- 17What is fatty acid synthase? Where in the cell can it be found?Fatty acid synthase is one big molecule containing all the enzymes involved in fatty acid synthesis on one polypeptide chain. it is located in the cytoplasm.
- 18What does ACP stand for?Acyl carrier protein. (similar to CoA and functions in the same way).
- 19True or false: all substrates in fatty acid synthesis are bound to ACP?True.
- 20Why does allosteric binding of citrate cause partial reactivation of the enzyme acetyl CoA carboxylase?Because lots of citrate indicates that the cell has lots of building blocks and precursors form the TCA. Therefore breakdown of fatty acids for energy is not required?
- 21How is acetyl CoA carboxylase regulated allosterically?Allosteric regulation occurs when citrate binds to the phosphorylated form of the enzyme. It causes the enzyme to partially reactivate.
- 22What is the result of phosphorylating the enzyme acetyl CoA Carboxylase? Does this reaction require ATP?It causes the enzyme to switch off completely and prevents fatty acid synthesis. It does require ATP.
- 23What are the two ways in which acetyl CoA Carboxylase is regulated?Allosteric mechanism and covalent modification via phosphorylation.
- 24What is the first regulatory point in fatty acid synthesis?The first reaction - acetyl CoA carboxylase
- 25What kind of reaction is the first reaction in fatty acid synthesis? Does it use ATP?A carboxylation reaction? Yes.
- 26Which reaction is the commited, rate limiting step in fatty acid synthesis?The first step - the reaction to convert Acetyl CoA to Malonyl CoA
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- Flashcards on Fatty Acid Synthesis, created by sophiakostich on 06/05/2013.
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- sophiakostich · May 2013
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- Sep 16, 2016
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