Created by gina_evans0312
over 10 years ago
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Question | Answer |
Location | Secondary lymphoid organs |
Trapping B Cells- Naive B Cells | Pass through the lymph node during normal circulation- if they encounter their Ag, they become partially activated and trapped in the lymph node |
Trapping T Cells- Dendritic Cells | Ag loaded dendritic cells migrate from the tissues to the paracortex of the lymph node |
Trapping T Cells- Naive T-Cells | Naive T cells pass through the parcortex and are trapped by the presented Ag |
Trapping T Cells- T-Cell Activation | In the presence of their Ag, that activate, proliferate, and become primed |
Forming the Primary Follicle- Proliferating B & T Cells | B & T cells are now in close enough proximity for the changes of them both responding to the same Ag to be high |
Forming the Primary Follicle- Th Dependent Activation | Through linked recognition, the B cell binds the Ag, and presents it to the T cell using MHCII |
Forming the Primary Follicle- Secondary Signal | The primed T cell now provides the secondary signal for B cell activation, leading to the formation of a germinal centre |
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