769274
Description
Flashcards by gina_evans0312, updated more than 1 year ago
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Created by gina_evans0312
over 10 years ago
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| Question | Answer |
| Definition | Blood glucose below 2.2mM |
| Effects | Same as cerebral anoxea- blurred vision, lethargy, agitation, mood swings, coma and brain damage |
| Alcohol Induced Hypoglycaemia- Effect | Ethanol metabolism in the liver decreases NAD+ availible for glycogenlysis/gluconeogenesis |
| Alcohol Induced Hypoglycaemia- Ethanol Dehydrogenase Reaction | Ethanol + NAD --> Acetaldehyde + NADH |
| Alcohol Induced Hypoglycaemia- Acetaldehyde Dehydrogenase Reaction | Acetaldehyde + NAD+ --> Acetic Acid + NADH |
| Alcohol Induced Hypoglycaemia- NADH Issues | The large vol. of NADH prod. shifts the equilibrium of enzymes that rely on NAD |
| Alcohol Induced Hypoglycaemia- Substrate Issue | Very rapid with no control system, there are no substrates left for OAA, DHAP & pyruvate using reactions, so glucose cannot be made |
| Alcohol Induced Hypoglycaemia- Acetaldehyde Issues | Very toxic, forming adducts on proteins that prevent function leading to an immune response |
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