769310
Description
Flashcards by sophietevans, updated more than 1 year ago
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Created by sophietevans
over 10 years ago
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| Question | Answer |
| Where are mast cells found? | Mast cells can be found in a wide variety of tissues, including the skin, connective tissues of various organs, and mucosal epithelial tissue of the respiratory, genitourinary, and digestive tracts. |
| When do mast cells differentiate? | Their precursors, formed in the bone marrow by haematopoiesis, are released into the blood as undifferentiated cells - they do not differentiate until they leave the blood and enter the tissues. |
| What do mast cells have that they use in their immune responses? | They have large numbers of circulating granules, like circulating basophils, which contain histamine and other pharmacologically active substances. They play an important role in the development of allergies. |
| What would be seen in a histological stain of an eosinophil? | The eosinophil has a bilobed nucleus and a granulated cytoplasm that stains with the acid dye eosin red. |
| What proportion of circulating leukocytes do eosinophils constitute? | 1-3% of circulating leukocytes. |
| How are eosinophils like neutrophils and macrophages? | Like neutrophils, they are motile phagocytic cells that can migrate from the blood into the tissue spaces. |
| How do eosinophils differ from neutrophils in their function? | Their phagocytic role is significantly less important than that of neutrophils, and it is thought that they play a role in the defence against parasitic organisms by secreting the contents of eosinophilic granules, which may damage the parasite membrane. |
| How would a basophil appear histologically? | These have lobed nuclei and a heavily granulated cytoplasm that stains with the basic dye methylene blue. |
| What proportion of circulating leukocytes do basophils constitute? | They constitute <1% of circulating leukocytes. |
| How do basophils function? | Basophils are not phagocytic. They function by releasing pharmacologically active substances from their cytoplasmic granules and play a major role in certain allergic responses, along with mast cells. |
| Here is a picture of a basophil. |
Image:
basophil (image/png)
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| Here is a picture of an eosinophil. |
Image:
eosinophil (image/png)
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| Here is a picture of a mast cell. |
Image:
mastcell (image/png)
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