Connective Tissue

Fibrillogenesis
1. 1. Type 5 and 11 form a fibrillar core
  1. 2. Type 1 col. molecules are deposited and polymerised on the core
    1. 3. Small amounts of Type 2 and 3 col. molecules are incorporated into T1 col. fibrils
Elastic fibres
1. Accumulated EFs= yellow
2. Stain: Orcein (red-brown)
3. Loose CT Proper
Reticular fibres
1. Type III Col. fibrils embedded in glycoCHON matrix
2. Supporting network for cells in liver, glands and muscle tissue
3. Stain: Ag impregnation, PAS run
4. Reticular tissues- creates storm of hemopoietic organs
Ground Substance
1. GAGS
2. Hyaluronic acid
3. Sulphated GAGs
4. Proteoglycans
5. Multiadhesive glycoproteins
Cartilage
1. Hyaline
2. Elastic
3. Fibrocartilage
Components
1. GAG
  1. Decorin
  2. Perlecan
  3. Syndecan
2. Proper CT Cells
  1. Dense collagen- CT Proper
    1. Aniline blue
    2. T1 collagen form thick bundles in reticular, skin, sclera and joint fascia
3. Collagen
  1. Staining: HE= Pink, Trichromes= named colour
  2. T1: form fibres
  3. T2: cartilage
  4. T3: reticular fibre
  5. Biosynthesis of T1
    Annotations:
    - 1. Collagen alpha chains are syn. in RER 2. Post-translational modification take place within the RER cisternae 3. Triple helix is formed with the help of hsp47 4. Intrachain and interchain H and S bonds form --> shape is influenced 5. Procollagen molecules --> Golgi --> Secretory vesicles --> Exocytosis 6. Fibrillogensis occurs
  6. Fibrillar: 1,2,3,5,9
  7. Hexagon forming: 8, 10
  8. Basement membrane: 4,6,7
  9. Degradation:
    1. Proteoglycan
    2. Phagocytotic
4. Dense Regular CT
  1. Parallel bundles of collagen fibres
5. Specialised types of CT
  1. Elastic: Orcein (red-brown)
  2. Reticular: AgNO3 (black)
  3. White adipose tissue
Collagen fibres
1. Closely packed Type 1
2. Stains with acid dyes: eosin, aniline blue
3. Found in: CT Proper, fibrocartilage

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Connective Tissue

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	Created by Celina Gupta about 6 years ago