298431
Description
Lymphocytes
- Origin and Development
- Positive Selection
- ensures survival of lymphocytes that react against
antigens. These proliferate and form clones.
- ensures survival of lymphocytes that react against
antigens. These proliferate and form clones.
- Negative Selection
- eliminates clones that
react against self-antigens
- eliminates clones that
react against self-antigens
- Positive Selection
- B and T cells
- originate in bone marrow
- move to primary lymphatic
organs where they mature
into functional cells.
- B cells to bone marrow
- T cells to thymus
- B cells to bone marrow
- secondary lymphatic organs interact
with each other which produces the
immune response
- originate in bone marrow
- Activation
- must be able to recognize the
antigen and destroy it.
- Antigenic determinants: specific
regions of antigen recognized by
lymphocytes
- Antigenic Receptors (T
and B cell receptors)
- surface of lymphocyte
that combines with
antigenic determinant
- surface of lymphocyte
that combines with
antigenic determinant
- MHC complex
- glycoprotein molecules which
have a variable region that bind
to foreign and self antigens
- glycoprotein molecules which
have a variable region that bind
to foreign and self antigens
- must be able to recognize the
antigen and destroy it.
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