3594449
Description
Mind Map by Sarah Smith, updated more than 1 year ago
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Created by Sarah Smith
about 9 years ago
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Cell adhesion and migration
- Adhesion
- Cell adhesion molecules (CAMs)
- Tight/occluding junctions
- Anchoring junctions
- Cadherins
- Need catenins to
bind to actin
microfilaments
- B-catenin
- B-catenin
- E-cadherin limits tumour
spread, thus is tumour
suppressor
- Need catenins to
bind to actin
microfilaments
- Integrins
- Alpha chain contains metal
coordination complex
- Integrins are CAMs
that mediate cess
migration
- Almost all interact
with
microfilamants,
but one interacts
with intermediate
filaments
- MIDAS site need Ca2+ or Mg2+
- Alpha chain contains metal
coordination complex
- Focal Adhesions
- Hemidesmosomes
- Desmosomes
- Adherens junctions
- Cadherins
- Communicating Junctions
- Lack of adhesion -
tumour development
- Interdependent with differentiation
- Cell adhesion molecules (CAMs)
- Migration
- Multicellular animals
- Most cells need a sold
support; ECM or other cells.
- Most cells need a sold
support; ECM or other cells.
- Cilia and Flagellae: bundles of
microtubules...relationship with
cytoskeleton
- Cells of the nervous
system migrate from the
neural crest during
embryonic development
- Pseudopodia:
stubby projections at
cell's leading edge
- Leading edge of cell
anchored by integrins
- Leading edge of cell
anchored by integrins
- Lamellipodium: sheet
of cytosol extended at
leading edge
- Filopodia: single
filamentous extensions
- Uropod: trailing edge
- Multicellular animals
- Cells need survival signals
from basal
lamina/neighbouring cells
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