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517506
retinoblastoma
Description
Paediatrics (Malignancy) Mind Map on retinoblastoma, created by v.djabatey on 31/01/2014.
No tags specified
malignancy
paediatrics
paediatrics
malignancy
Mind Map by
v.djabatey
, updated more than 1 year ago
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Created by
v.djabatey
over 10 years ago
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Resource summary
retinoblastoma
malignant tumour of retinal cells
rare
but = 5% of severe renal impairment in kids
an affect one or both eyes
all bilat tumours (& 20% of unilat) are hereditary
susceptibility gene
chromosome 13
dominantly inherited, but incomplete penetrance
most cases present 0-3 years old
kids from families w/ hereditary form
regular screening from birth
clinical features
white pupillary reflex
commonest presentation
squint
Ix
under anaesthetic
MRI
examination
NO BIOPSY
Rx
aim to cure but preserve vision
Rx based on ophthalmological findings
enucleation of eye
for more advanced disease
chemo
in bilat disease
shrink tumour
fb local laser Rx to retina
radiotherapy
mostly for Rx of recurrence
can be used in adv disease
tumours often multifocal
most are cured but many visually impaired
sig risk of 2nd malignancy esp sarcoma among hereditary retinoblastoma survivors
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