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WOUND HEALING 2
Description
Bio Med and Pathology Mind Map on WOUND HEALING 2, created by aahughes on 21/04/2013.
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bio med and pathology
bio med and pathology
Mind Map by
aahughes
, updated more than 1 year ago
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Created by
aahughes
over 11 years ago
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Resource summary
WOUND HEALING 2
HEALING BY SECONDARY INTENTION
When there's on going tissue damage from infection
Significant tissue loss where edges of wound cannot be brought together
Granulation tissue formed
Scar contraction greater + re epithelisation less
INFLAMMATION
separation of necrotic tissue: phagocyte action within exudate
Necessary part of healing: clearing debris and inducing proliferation
Lasts as long debris is in the wound
PROLIFERATION
begins as granulation tissue: new capillary buds, phagocytes and fibroblasts
Reaches dermis epithelial cells, proliferates from edges to centre
Formation of granulation tissue is essential in open wound
Epithelial cells migrate across new tissue to form a barrier
MATURATION AND RE-MODELLING
Granulation tissue replaced by scar tissue
scar tissue: increase in extracellular collagen, inflame cells dissapear
collagen matures and contracts
GRANULATION TISSUE
Commonly seen with fresh healing tissue
Macroscopically appear as red granular areas which bled easily
fragile newly formed capillaries which proliferate and grow
contains chronic inflam cells
SCAR FORMATION/FIBROSIS
Forms when there is a large area of tissue damage
cells do not regenerate due to ischemia, suppuration
starts with granulation tissue the inflam material is removed
Only collagen fibres remain
EFFECTS OF SCAR TISSUE
ADHESIONS: may limit movement
FIBROSIS: blockage of an end vessel
SHRINKAGE: as fibrous tissue ages, limited movement
FACTORS INFLUENCING HEALING
LOCAL: persisting infection, foreign mat, or stimuli
Poor blood supply
Irradiation
Locally applied drugs, corticosteroids
SYSTEMIC: age and nutrition
metabolic disease ie diabetes
Malignancies
DENTAL EXTRACTIONS
healing by Secondary Intention as there is wide separation
PHASES OF WOUND HEALING
INFLAM PHASE: coagulation provides clot, provides initial tissue for migration of cells
Platelet plug and secret mediators that attract macrophages and fibroblasts
PROLIFERATION PHASE: fibroblasts +endo cells from remains of perio membrane
MATURATION REMODELLING: woven bone is remodelled
formation of cortical and cancellous bone
reduction of height in alveolar bone. Site healed in 20-30 weeks
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