ADAPTIVE IMMUNE RESPONSE

Details:
1. Innate vs Adaptive
2. Non-specific vs Specific
3. Immunological memory is not stored vs Immunological memory is stored
1. Development of T and B cells
1. Lymphocyte: T cells( thymus ), B cells( bone marrow )
2. Have surface markers/receptors: 1. bind to receptors on other cells 2. Bind to antigens 3. Transmit and receive messages
3. Common receptor: 1. MHC 2. CD 3. Antigen-specific receptors
4. MHC class: Class I, Class II (the focus), Class III
5. CD Molecules: CD4 for Class II, CD8 for Class I
6. Clonal Deletion
2. Presentation of antigens
1. Happen in secondary lymphoid organ
2. Antigens is substance that provoke immune response
3. Have epitope- antigenic determinant site
4. Combination factors: size, complexity, foreigness
5. APC's: macrophages, dendritic cells, B cells
6. T cells- T receptors (TCR)
7. B cells- immunoglobulins (Ig) / antibodies: Ig G, Ig A, Ig M, Ig E, Ig D
T-cell response
1. differentiation: 1. subtypes of T helper cells (Th), 2. memory T cells, 3. regulatory T cells, 4. cytotoxic T cells
2. CD 8: cytotoxic T cells attack * infected host * cancerous host cells * foreign cells from outside
3. CD 4: helper T cells stimulate or activate other cells * macrophage * B cells * T cells
B-cell response
1. T-independent cells activation ( just small amount)
2. Differentiation: memory B cells, neutralisation, antitoxin action

Resource summary

	Created by Nurainaa Azra'i over 8 years ago