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54515
Cells of the Immune System
Description
Biochemistry (Immunity) Mind Map on Cells of the Immune System, created by zambrella on 23/04/2013.
No tags specified
biochemistry
immunity
biochemistry
immunity
Mind Map by
zambrella
, updated more than 1 year ago
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Created by
zambrella
over 11 years ago
139
1
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Resource summary
Cells of the Immune System
Leukocytes (white blood cells)
Small lymphocyte
Production of antibodies (B cells) or cytotoxic and helper functions (T cells)
Natural killer cell
Kills cells infected with certain viruses
Plasma cell
Fully diferentiated form of B cell that secreted antibodies
Dendritic cell
Activation of T cells and initiation of adaptive immune response
Sessile dendritic cells
Contact with external environment e.g. skin
Neutrophil
Phagocytosis and killing of microorganisms
Large range of receptors that mediate recognition and phagocytosis
Pattern recognition receptors (PRRs) that detect microbial associated molecular patterns (MAMPs)
Toll-like receptors (TLRs)
NOD-like receptors (NLRs)
RIG-I-like receptors (RLRs)
Other cytosolic nucleic acid sensors
C-type lectin receptors (CLRs)
Receptors that detect signalling proteins e.g. cytokines
Peptidoglycan recognition proteins (PGRPs)
Some are lymphocyte surface associated
Some are intracellular
Some are circulating
Recognise, opsonise and some may be directly antimicrobial
Can make alpha-defensins
Pore forming peptide antibiotic
Basopohil
Unknown
Eosinophil
Killing of antibody-coated parasites through release of granule contents
Mast cell
Expulsion of parasites from body through release of granules containing histamine and other active agents
Monocyte
Circulating precursor cell to macrophage
Macrophage
Phagocytosis and killing of microorganisms. Activation of T cells and initiation of immune response
Motile mactrophages
Patrol tissues acting as a first line of defence
Act as scavengers that rid the body of worn-out cells and other debris
Subcategorised depending on anatomical location
Alveolar (lungs)
Osteoclasts (bone)
Microglia (brain)
Kupffer cells (liver)
Have receptors that can talk to T-cells and mediate adaptive immunity
Lymphocyte
Travel via the lymphatic system
Lymph nodes act as sites of communication between lymphocytes
Use confocal microscopy and staining to study cells
Green fluorescent protein (GFP)
Recognition by lymphocyte
Acid
Toxic oxygen derivatives
Peptides and proteins
Enzymes
Competitors
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