5608144
Description
Mind Map by Queeny MCAT, updated more than 1 year ago
|
Created by Queeny MCAT
about 8 years ago
|
|
Molecular Genetics
- Transcription
- Initiation
- Step-By-Step
- Promoter recognized by
Transcription Factors
- RNA Pol. II
recruits by
transcript factors
- Transcription
begins and
continues 3'-5'
along template
strand
- Transcription
begins and
continues 3'-5'
along template
strand
- RNA Pol. II
recruits by
transcript factors
- Promoter recognized by
Transcription Factors
- Step-By-Step
- Elongation
- Complementary
RNA nuctids. add
to growing RNA
(U/T)
- Complementary
RNA nuctids. add
to growing RNA
(U/T)
- Termination
- Step-by-Step
- Polyadenylation
signals to cut from
polymerase
- RNA is PRE-mRNA
- RNA Pol.
falls off
template
strand
- RNA Pol.
falls off
template
strand
- RNA is PRE-mRNA
- Polyadenylation
signals to cut from
polymerase
- Step-by-Step
- Purpose
- Converts
DNA to RNA
- Protects
information
- Multiple RNA
copies for more
protein
production
- Converts
DNA to RNA
- Post-Transcript
Mods
(Eukaryotes
Only)
- Purpose
- Export of
mRNA from
nucleus
- Protect
mRNA
from
degradation
- Facilitated
proper
translation
- Export of
mRNA from
nucleus
- 5' Capping
- Modified
guanine
- Add 5' end during
transcript
- Add 5' end during
transcript
- Modified
guanine
- Poly-A-Tail
- multiple
adenines
added at end
of signal--3'
- multiple
adenines
added at end
of signal--3'
- Intron Splicing
- Spliceosome
- Removes
introns
(snRNA)
- Products:
mature mRNA
and circular
intron
- Products:
mature mRNA
and circular
intron
- Removes
introns
(snRNA)
- Alternative
Splicing
- 1 gene
codes
multiple
proteins
- 1 gene
codes
multiple
proteins
- Spliceosome
- Purpose
- Initiation
- Translation
- Purpose
- Convert
mRNA to
Protein
- Convert
mRNA to
Protein
- Ribosomal
Structure
- Large
Unit
- Small
unit
- Small
unit
- mRNA
Binding
Sites
- Exit
- Peptidyl-tRNA
bind
site
- Aminoacyl
tRNA Bind
site
- Exit
- Reading
Frame
- Codons
- 3 mRNA
Nucleotides and 1
amino acid
- Stop
- UAG,
UAA,
UGA
- UAG,
UAA,
UGA
- 3 mRNA
Nucleotides and 1
amino acid
- Codons
- adapters with
an anticodon
- Each bind
to ONE
specific
amino acid
at
Carboxylic
Acid
- Large
Unit
- Initiation
- tRNA
(Transfer
RNA)
- Step-by-step
- Initiator
t-RNA
(methionine)
binds
to
small
unit
with
initiation
factors
- small
ribosomal
subunit/initiator
t-RNA
binds
m-RNA
5'
cap
to
5'
end
- Scan
toward 3'
end until
start
codon
- AUG
- AUG
- Scan
toward 3'
end until
start
codon
- small
ribosomal
subunit/initiator
t-RNA
binds
m-RNA
5'
cap
to
5'
end
- Initiator
t-RNA
(methionine)
binds
to
small
unit
with
initiation
factors
- Step-by-step
- tRNA
(Transfer
RNA)
- Elongation
- Step-by-step
- Current
tRNA at
P-Site
- moving
toward
3'New
tRNA add
to A-site
- AA ads to
carboxy
end
- Chain
grows to
A-site
- Large shifts
1st one
codon
- Small
shifts
- tRNA in P-site now in
E-site and A-site now
P-site
- E-site Ejects and new
A-site tRNA is added
- E-site Ejects and new
A-site tRNA is added
- tRNA in P-site now in
E-site and A-site now
P-site
- Small
shifts
- Large shifts
1st one
codon
- Chain
grows to
A-site
- AA ads to
carboxy
end
- moving
toward
3'New
tRNA add
to A-site
- Current
tRNA at
P-Site
- Step-by-step
- Termination
- Step-by-step
- When A-site
reads stop
codon
- UAG,
UAA,
UGA
- Release
factor
releases
peptide
chain
and
ribosomes
dissociate
- Release
factor
releases
peptide
chain
and
ribosomes
dissociate
- UAG,
UAA,
UGA
- When A-site
reads stop
codon
- Step-by-step
- Purpose
- Gene
Expression
- Purpose
- efficiency
and
adaptive
- cells have
same
genome;
need
regulation
- Results in
different cell
types
- efficiency
and
adaptive
- Step-By-Step
- 1. DNA-->RNA (single)
- 2. RNA to mRNA
- 3. Out of
Nucleus
thought Nuc
pore; direction
- 4. Translation
Route-->Protein
- Protein-->Activated!
- Protein-->Activated!
- 5. Degredation Route
- 4. Translation
Route-->Protein
- 3. Out of
Nucleus
thought Nuc
pore; direction
- 2. RNA to mRNA
- 1. DNA-->RNA (single)
- Purpose
- Protein
Degredation
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