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IMMUNISATION OF CARIES

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ORAL BIOLOGY Mind Map on IMMUNISATION OF CARIES, created by aahughes on 24/04/2013.
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Mind Map by aahughes, updated more than 1 year ago
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Created by aahughes almost 12 years ago
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IMMUNISATION OF CARIES
  1. VACCINATION AGAINST S.MUTANS
    1. BOWEN 1969: Injected live strain of S.mutans IV to monkeys
      1. they were then fed a cariogenic diet
        1. After 1yr: control - 38 cavities+13 early lesions
          1. Vaccinated - 6 cavities+4 early lesions
            1. 2nd EXPERIMENT: broken cells of S.mutans injected into oral mucosa
              1. Control- 64 cavities
                1. Vaccinated - 0 cavities
    2. RAT STUDIES
      1. S.mutans administered via subcutaneous inoculation
        1. this induced salivary sIgA
          1. they were then inoculated with the bacteria, reduced level bacteria recovered
            1. Hence reduced carious lesions
      2. ANTIGEN OF S.MUTANS
        1. Protein antigen I/II
          1. Glucosyltranferase - accumulation
            1. Glucen binding proteins - phase III
              1. Lehner 1980 - monkey experiments
        2. Enter text here
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