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AMELOGENISIS
- ENAMEL is a highly mineralised epithelial product
- NOT a connective tissue
- It composes of 96% mineral - mainly HYDROXYAPATITE
- Contains 1-2% organic matrix: enamel proteins
- Its composed of another 2% WATER
- Enamel begins to form after dentine
- Enamel begins to form after dentine
- Its composed of another 2% WATER
- Contains 1-2% organic matrix: enamel proteins
- It composes of 96% mineral - mainly HYDROXYAPATITE
- NOT a connective tissue
- 1.Inner Enamel Epithelium mature from cuboidal to columnar cells
- 2.Pappilla cells divide to form Odontoblasts
- IEE begins to polarise and form preameloblasts
- 3.Papilla cells migrate across acellular zone where they become odontoblasts
- 5.Predentine mineralises against Basal Lamina
- 6.More Dentine forms and Basal Lamina desintegrates
- 7.Ameloblasts move upwards and outward
- 9.Tomes Process forms on ameloblasts which provides a prism structure to enamel
- They continue to retreat and lay down enamel
- They continue to retreat and lay down enamel
- 9.Tomes Process forms on ameloblasts which provides a prism structure to enamel
- 5.Predentine mineralises against Basal Lamina
- As they move away they leave a process behind through Basal Lamina
- 4.Odontoblasts retreat and Preameloblasts get larger
- 4.Odontoblasts retreat and Preameloblasts get larger
- 3.Papilla cells migrate across acellular zone where they become odontoblasts
- IEE begins to polarise and form preameloblasts
- 2.Pappilla cells divide to form Odontoblasts
- FORMATION OF ENAMEL
- PREAMELOBLASTS
- Polarised and contains lots of Mitochondria, RER,Golgi Apparatus
- Basal Lamina disintegrates and PA becomes ameloblast
- It then secretes enamel proteins that become mineralised
- Terminal Web is the line between cells
- Terminal Web is the line between cells
- It then secretes enamel proteins that become mineralised
- Basal Lamina disintegrates and PA becomes ameloblast
- Polarised and contains lots of Mitochondria, RER,Golgi Apparatus
- AMELOGENISIS:Dentine formation and breakdown of Basal Lamina
- Ameloblast secretes organic matrix
- Ameloblast secretes organic matrix
- ENAMEL MATRIX
- Laid down as an amorphous gel
- Consists of enamel proteins and enzymes
- amelogenins, enamelins,
- amelogenins, enamelins,
- Consists of enamel proteins and enzymes
- Laid down as an amorphous gel
- AMELOGENINS
- Rich in Proline and Glutamate
- Hydrophobic hence packed together
- spread through enamel thickness
- spread through enamel thickness
- Hydrophobic hence packed together
- Rich in Proline and Glutamate
- ROLE OF ENAMEL PROTIENS
- Aid neucleation of Hydorxyapatite
- No matrix vesicles
- Tuftelin may have a role
- there is an immediate partial mineralisation of secreted matrix
- Followed by rapid crystal growth
- Followed by rapid crystal growth
- No matrix vesicles
- Aid neucleation of Hydorxyapatite
- MATURATION
- Thin crystals grow in thickness
- Requires mineral ions to come in
- Enzymes break down amelogenins
- Enzymes break down amelogenins
- Requires mineral ions to come in
- Thin crystals grow in thickness
- ENAMELINS:protein of ameloblasts or product of amelogenins
- MATURATION
- Enamel thickness laid down, Tomes Process is lost
- Enamel thickness laid down, Tomes Process is lost
- ENAMEL CUTICLE
- Formed when maturation is complete
- Formed when maturation is complete
- REDUCED ENAMEL EPITHELIUM
- Formed when enamel is complete
- attached to enamel cuticle
- Protect enamel surface from resorption
- Provides and epithelial pathway for eruption
- Form initial Junctional Epithelium
- Form initial Junctional Epithelium
- Provides and epithelial pathway for eruption
- Protect enamel surface from resorption
- attached to enamel cuticle
- Formed when enamel is complete
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