Th1L06 Intermediate Filaments

Description

Medicine Y1 (Theme 1 | Cells and organelles) Mind Map on Th1L06 Intermediate Filaments, created by Emma Allde on 16/08/2016.
Emma Allde
Mind Map by Emma Allde, updated more than 1 year ago More Less
Emma Allde
Created by Emma Allde over 8 years ago
Emma Allde
Copied by Emma Allde over 8 years ago
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Resource summary

Th1L06 Intermediate Filaments
  1. structure
    1. polymer of individual intermediate filament proteins
      1. Formation
        1. (1) intermediate filament protein (monomer) forms a helical dimer
          1. (2) two dimers combine to form a tetrameter
            1. (the fundamental units of the IF)
            2. (3) tetramers link in a staggered formation and end-to-end to form the filament
          2. 10nm in diameter
            1. visible by electro microscope
            2. not dynamic
              1. functions
                1. anchor cells at some cell junctions
                  1. from a meshwork around the cell nucleus to hold it in place
                  2. support nuclear structure
                    1. Stabilise the shape of axons

                      Annotations:

                      • NB: so do MTs
                    2. act as diagnostic tools to identify foreign cells as they are expressed differently based on their different locations (e.g. cancer)
                    3. common types
                      1. keratin, vimentin, glial fibriallary acidic protein, neurofilamin
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