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65204
Transplantation
Description
Mind Map on Transplantation, created by sam.hilton on 01/05/2013.
Mind Map by
sam.hilton
, updated more than 1 year ago
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Created by
sam.hilton
over 11 years ago
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Resource summary
Transplantation
Transplantable tissues
Skin
Kidnney
Liver
Heart
Lung
Pancreas
Cornea
Bone Marrow
Face
Types
Autograft
Allograft
Isograft
Xenograft
Problems
Antibodies
Hyperacute rejection
Alpha1-3Gal
transgenic pigs?
Complement
PERVS
Matching
MHC
MLR
ABO
Graft rejection
Types
Hyperacute
ABO missmatch
Pre existing antibodies
Acute
MHC missmatch
Chronic
T cell response
Direct/indirect allorecognition
Minor H antigens
MHC I
Polymorphic self proteins
GVHD
Immunosuppresive drugs
Cyclosporin A
Tacrolimus
Blocks calcineurin
dephosphorylation of NF-AT blocked
IL-2 blocked
Sirolimus
Binds mTOR
Prevents cell cycle in t cells
Side effects
Other drugs
Prednisone
Azathioprine
Anti-CD3 antibodies
siRNA
Tregs
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