Loading [MathJax]/jax/output/HTML-CSS/fonts/TeX/fontdata.js

Genetics and Evolution VII

Descrição

FlashCards sobre Genetics and Evolution VII, criado por J yadonknow em 05-03-2018.
J yadonknow
FlashCards por J yadonknow, atualizado more than 1 year ago
J yadonknow
Criado por J yadonknow quase 7 anos atrás
3
0
1 2 3 4 5 (0)

Resumo de Recurso

Questão Responda
What are the 3 causes of large insertion? Transposon mobilisation Virus insertion Retroposition
Tranposon mobilisation MOA (2) Excision via transposases autonomously encoded by their own DNA Insertion into various regions of the genome.
What is retroposition? RNA transcript -> DNA -> Integration into genome
What are the causes of large deletions? Transposon mobilisation Incorrect repair of ds DNA break
How do transposon mobilisations cause deletions? As they can take chunks of non-transposon DNA with them when they jump.
What occur during incorrect ds DNA repair? (2) Sometimes isn't possible to use homologous chromosome as template for repair Just sticks broken ends back together
What are the list of bigger changes? (5) Translocation (1) Reciprocal translocations (2) Inversion (3) Duplication (4) Chromosome fusion/fission (5)
What is translocation? Movement of a region of genome
What is a reciprocal translocation? Swap 2 regions of genome
What is inversion? Excision, flip, paste back.
What is duplication? Excision, replicate, stick both back in.
What is chromosome fusion/fission? Fuse 2/split 1 into 2.
Spit me some bs about Ph Chromsome (3) t(9;22)(q34;p11.2) Abl repressor domain and protein kinase domain PK is fused to bcr domain instead of abl, so kinase isn't repressed.
What is gene function allocation due to duplication? One can specialise and the other does all the work They both split the function between the two of them
Dominant LOF alleles are of a haplo-insufficient locus e.g. HPE4
Dominant GOF allele mutation changes (3) Mutation changes specificity of enzyme so it binds a different substrate Mutation changes gene expression patterns Changes pheno.
Dominant negative (antimorphic) mutation (2) Mutant protein competes / counteracts WT protein e.g. binds irreversibly to substrate so WT can't bind.
Recessive allele mutations - degrees of mutation Complete LOF Partial LOF - still produces protein, comprised.
When does a change in DNA become a mutation? When the change is inheritable. Cells that aren't diving may leave damage unrepaired.
Name the 5 mechanisms of DNA repair Direct reversal Mismatch repair BER NER Homologous recombination
What can cause inaccurate repair? (2) Translesion DNA synthesis Non-homologous end joining
What are the mutation rates of humans/E.coli? 1.2x10^-8 8.9x10^-11

0 comentários

There are no comments, be the first and leave one below:

Semelhante

Resumo de Biologia - Ciclos da Vida e Evolução
Larissa Guimarães
Guia de Estudos do ENEM 2014
Alessandra S.
CAE - Cambridge Advanced: English
Luiz Fernando
Literatura - Escolas Literárias
Amanda Destro
DIREITO PROCESSUAL PENAL
Joelma Silva
A Era Vargas (1930-45)
kl.a.b
Ética para OAB
Maria José
FIGURAS DE LINGUAGEM
Gabriela Vianna
Exercícios- Tipos de Reprodução
Andrea Barreto M. Da Poça
Falsos Sinônimos
Alessandra S.