21972185
Descrição
FlashCards por Evian Chai, atualizado more than 1 year ago
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Criado por Evian Chai
mais de 4 anos atrás
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| Questão | Responda |
| What is the difference between SNS and PNS effects on Vascular tone? | 1. PNS causes selective vasodilation (salivary glands, pancreas, sex organs, intestine) and doesn't impact TPR 2. SNS redistributes blood and can affect TPR |
| What is the difference between adrenaline and noradrenaline? | Noradrenaline maintains myogenic tone and is released constantly Adrenaline is released by the adrenal medulla mainly, and is only during fight/flight. It uniquely binds to B2 |
| What occurs when noradernaline binds to B1/A1 receptors? | B1: Increase HR/cardiac contractility A1: Vasoconstriction of most vascular beds |
| What occurs when adrenaline binds to B1/A1/B2 receptors? | B1: Increase HR/cardiac contractility A1: Vasoconstriction of most vascular beds B2: VASODILATION of heart/liver/skeletal muscle arterioles |
| What do the following hormones cause? 1. Angiotensin II 2. Vasopressin (ADH) 3. Atrial Natriuretic | 1. Vasoconstriction 2. Vasoconstriction, an increase in blood volume 3. Vasodilation |
| What signal does the PNS send and what does it do? | ACh, binds muscarinic receptors on pacemaker to lower HR |
| What signal does the SNS send and what does it do? | Noradernaline, binds to: 1. B1 receptors on pacemaker (increase HR) 2. B1 receptors on myocardium (increase contractile force) |
| What does vascular tone determine? | 1. BP, TPR, CO 2. Distribution of blood |
| How does myogenic autoregulation contribute to vascular tone? | Arterioles respond to increase in pressure by increasing contraction Protects glomerulus from too high pressure |
| How do Prostanoids (prostaglandins and thromboxanes) affect vascular tone? | Vasoconstrictors: TXA2, PGF2 Vasodilators: PGE, PGI |
| How does Bradykinin affect vascular tone? | 1. Vasodilation through production of nitric oxide 2. Increase vascular permeability |
| How does histamine affect vascular tone? | Mast cells release to: 1. Vasodilation (nitric oxide) 2. Increase vascular permeability |
| How does nitric acid affect vascular tone? | 1. Endothelial nitric oxide synthase in endothelial cells make NO, diffuse to smooth muscle 2. Leads to calcium storage in sarcoplasmic reticulum/no cGMP = no contraction 3. So vasodilation |
| What is endothelial nitric oxide synthase in endothelial cells stimulated by? | Laminar flow, Ca2+ |
| What are the 5 determinants of BP? | 1. Stroke Volume 2. Heart Rate 3. Total peripheral resistance 4. Central venous pressure 5. Blood volume |
| Where are the mechanoreceptors for the baroreceptor reflex located? | Aortic arch and carotid sinus |
| What does increased BP lead to? | Increased firing of baroreceptors |
| What are the effects of increased baroreceptor firing? | Increases PNS activity (release ACh to pacemaker cells) Decreases SNS activity on cardiac myocates (fall in HR, CO, Contractile force, TPR etc, vasodilation of vessels) Lowered BP |
| What nerves do signals from the mechanoreceptors travel to the brain with? | 1. Vagus nerve 2. Glossopharyngeal nerve |
| How does blood volume regulate blood pressure in the Short vs. long term? | Short: raise in BV=raise in BP Long: raise in BV=excretion of excess fluid/salt=fall in BV/BP |
| What determines blood volume? | Plasma osmolarity |
| How does increased osmolarity impact blood volume? | Raise in thirst/ADH/water reabsorption Increase in BV |
| What does metabolic hyperaemia occur in response to? What happens? What is the main factor contributing to this? | Excercise Vasodilation Increase in metabolism+vasodilation allows muscles to get more nutrients etc. Local factors are the main factor causing increased blood flow |
| What does reactive hyperaemia occur in response to? What happens? | Blood flow cut off Metabolites accumulate and trigger vasodilation until washed out |
| How is thermoregulation achieved by the arteriovenous anatomoses? | Cold: Vasoconstriction Hot: Decrease in sympathetic, vasodilation, more blood to surface (dermal venus plexus), more heat loss |
| What does the skeletal muscle pump do? | Aids venous return in legs |
| Since diastolic pressure is the lowest pressure point in the cardiac cycle, how is BP maintained? | Energy stored in the elastic walls during systole released to mantain |
| What does renin do? | Converts angiotensin to angiotensin II |
| What does angiotensin II do? | 1. Vasoconstrictor 2. Stimulates ADH release, which increases H20 reabsorption 3. Stimulates release of aldosterone from adrenal gland to increase Na+ reabsorption Increased BV as result |
| What does a raise in BV lead to? | 1. Increased BV-->increased central venous pressure detected by mechanoreceptors 2. Vasodilation of afferent arterioles in glomerulus caused by Atrial Natrutiec Peptid-->increased GFR/water excretion 3. Lowered renin/Angiontensin II/ADH 4. As result, diuretics (more urine) and natriuresis (Na+ excretion)-->Lowered BV |
| What does pressure natriuresis occur in response to? What happens? | 1. Increased BV 2. local metabolite release in renal artery leads to vasodilation, increased natriuresis 3. Leads to fall in BV/BP |
| What is syncope? What is it caused by? | 1. Fainting due to blood/needles 2. Due to increase in PNS (lowered HR/Vasodilation) and lowered SNS (lowered CO/TPR=fall in BP+lowered blood flow to brain) |
| What are 3 functional adaptations of the pulmonary circulation? | 1) Low pressure 2) Unaffected by ANS, no metabolic regulation 3) Hypoxic pulmonary vascoconstriction - High CO2 will usually cause vasodilation but here it causes vasoconstriction to reduce blood to unoxygenated areas |
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