6669127
Descrição
FlashCards por Andrew Street, atualizado more than 1 year ago
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Criado por Andrew Street
mais de 7 anos atrás
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| Questão | Responda |
| Give eg's of & indications for antimuscarinic bronchodilators. | eg's: ipratropium, tiotropium, glycopyrronium Indications: • In COPD short-acting antimuscarinics are used to relieve breathlessness & long-acting antimuscarinics are used to prevent breathlessness and exacerbations. • In asthma, short-acting antimuscarinics are used as adjuvant Rx for relief of breathlessness during acute exacerbations. Long-acting antimuscarinics are added to high-dose inhaled corticosteroids & long-acting β2 agonists at ‘step 4’ in the treatment of chronic asthma. |
| MOA of antimuscarinic bronchodilators. | Antimuscarinics act as competitive inhibitors of acetylcholine thereby opposing parasympathetic effects & ^HR & conduction, reduce smooth muscle tone & secretions from glands in the respiratory & GI tracts. In the eye they cause pupil dilation. |
| SE's of antimuscarinic bronchodilators. | SE's: Few from inhalation as little systemic absorption. Dry mouth. |
| CI's, cautions, & important interactions of antimuscarinic bronchodilators. | CI's: • None Cautions: • Angle-closure glaucoma • Pt's at risk of arrhythmias Important interactions: Interactions are not generally a problem due to low systemic absorption. |
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