769298
Descrição
FlashCards por sophietevans, atualizado more than 1 year ago
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Criado por sophietevans
mais de 10 anos atrás
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| Questão | Responda |
| What are natural killer cells? | Large, granular lymphocytes. |
| What proportion of lymphocytes in peripheral blood do natural killer cells constitute? | 5-10% |
| Which cells do natural killer cells display cytotoxic activity against? | A wide range of tumour cells and cells infected with most (but not all) viruses. |
| Natural killer cells do not recognise tumour cells or virally infected cells by antigen as they do not have toll-like receptors or immunoglobulin in their cell membranes. How do they recognise their potential targets? | They have natural killer cell receptors (NKCRs) which distinguish changes abnormalities such as reduction in the display of MHC class I molecules on cell surfaces, or the unusual antigenic profile of the surfaces of some tumour and virus-infected cells. They also have CD16 receptors which bind to antibody, so if an antibody response has been raised, this can encourage natural killer cell involvement. This is antibody-dependent cell-mediated cytotoxicity. |
| What do natural killer cells look like when attack infected/tumour cells? |
Image:
nkcell (image/png)
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