Autonomic Nervous System

Adrenergic Pharmacology
1. A Receptors
  1. A1- Adrenerrgic antagonists
    1. MOA: Bind to A1 receptors, blocking SNS response
      1. eg. prazosin
        use: hypertension, peripheral vascular disease
        AE: hypotension, frequent urination
  2. A1- Adrenergic agonists
    1. MOA: Bind to A1 receptors, stimulating SNS response
      1. eg. phenylephrine
        use: hypotension, nasal congestion, red eyes
        Adverse effects: hypertension, blurred vision
  3. A2- Agonists
    1. MOA: bind to A2 receptors, stopping release of catecholamines
      1. eg. clonidine
        use: hypertension
        AE: dizziness, drowsiness, dry mouth/nose
2. B Receptors
  1. B1- Adrenergic agonists
    1. MOA: binds to B1 receptors, stimulating SNS response
      1. eg. dobutamine
        use: cardiac arrest, circulatory shock
        AE: hypertension, tachycardia
  2. B2-Adrenergic agonists
    1. MOA: binds to B2 receptors, stimulating SNS response
      1. eg. salbutamol, salmeterol
        use: COPD, asthma
        AE: tremor, tachycardia, ^ Blood glucose
  3. B-Antagonists/ Beta blockers
    1. MOA: bind to B receptors, blocking SNS response
      1. eg. carvedilol
        use: cardiac disease, hypertension
        AE: dizziness lethargy, insomnia
3. Non selective Adrenergic agonists:
  1. Bind to A and B receptors, stimulating SNS response
    1. eg. adrenaline, noadrenaline, dopamine
      1. Use: cardiac arrest, hypotension, shock
Cholinergic Pharmacology
1. Muscarinic Receptors
  1. Agonists
    1. eg. acetylcholine
      1. MOA: binds to muscarinic receptors, stimulating PNS response
        use: miotics
        AE: problems with eye accomadation
  2. Antagonists
    1. eg. atropine
      1. MOA: bind to muscarinic receptors, Blocking PNS response
        use: pre-med, dilation of pupils
        AE: dry mouth, blurred vision
2. Nicotinic Receptors
  1. Antagonists
    1. eg. vecuronium
      1. MOA: binds to nicotine receptors, blocking ACh binding
        use: pre-med
        AE: decreased BP
  2. Agonists
    1. eg. suxamethonium
      1. MOA: mimicts ACh & binds to nicotinic receptors
        use: short acting muscle relaxant
        AE: muscle spasm, hyperkalemia

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Autonomic Nervous System

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	Criado por Samara Watts aproximadamente 7 anos atrás