alveolar walls are folded to provide a large surface area
Many alveoli provide a large surface area so fast diffusion
Alveolar walls are thin so there's a short distance between the alveoli and blood/
Ventilation Maintains a diffusion gradient so fast diffusion
Heart
AVN delays electrical impulses Allowing atria to empty before ventricles contract
Atrium has higher pressure than ventricles so Atrio-ventricular valve opens
higher pressure in aorta so semi lunar valve closes
ventricle has higher pressure than aorta so semi-lunar valve
opens
ventricle has higher pressure than atrium so atrio-ventricular
valves close
AVN sends wave of electrical impulses down Bundle of His and Purkyne fibres ventricular
systole
oxygen travels through alveolar epithelium Through capillary
epithelium
SAN sends wave of electrical impulses across atria causing atrial contraction
immunity
how memory cells are important
Memory cells remain from previous infections / when an individual comes in contact with the
antigen again/ more antibodies produced to destroy the virus
Vaccine has dead pathogens/ T cells activate B cells/ b cells divide and produce antibodies / memory
cells are then produced for immunity
A anti-gen is a protein that causes immune response
Cholera
Cholera bacteria produces a toxin which causes chloride ions to move into lumen of the intestine.
Water potential of intestine falls / water moves by osmosis into intestine.
Lowers water potential in lumen so water enters intestine leaves the cells by
osmosis
Does not have a nucleus/nuclear envelope/has loop of DNA//no mitochondria / no golgi/ no
endoplasmic reticulum/Small Ribosomes/ Capsule/flagellum/plasmid / cell wall/
How science works
factors that increase risk of CHD
Smoking/age/genes/high blood pressure/gender alcohol/lack of exercise/obesity/stress
random selection avoids bias. / Control groups are To ensure that results are not due to some other substance./
Denature at 30, active site is distorted, no more es complexes can form
Allows comparison Idea that weights/Idea that cylinders have
different starting masses
high substrate concentration = higher ROR but will plateau
Line of best fit is more reliable / point where line crosses axis is more
reliable - (additional readings)
CELLS/Adaptations
Adaptions of epithelial cells
carrier protein for sodium (ions) and glucose
carrier proteins for facilitated diffusion
Carrier proteins for active transport
Many mitochondria provide energy for
active transport
Microvilli increase surface area
Asthma narrows airways/ Air in alveoli is not replaced as
efficiently / Difference in concentration of oxygen is lowered so
rate of diffusion lower
Hydrolysis is the opposite of condensation reaction ( adds h20)
Enzymes being specific
Enzymes Active site has a specific structure so it does not bind with other lipids, so it
does not form enzyme-substrate complexes
(induced fit) Active site is not complementary/the active site changes is
flexible/Change in enzyme allows E-S complex to form
Competitive inhibitorsHave similar structure so will compete to the complementary active site. This causes less enzyme substrate complexes to be
formed
Homoginisation - releases organelles
Isotonic - Prevents osmosis So organelle named organelle is not
damaged
Ice Cold - Reduces enzyme activity
Filtration - Removes cell debris
Buffer solution maintains a constant Ph
Tem/sem
Cannot look at living cells /Tem is high resolution/ black n white/ large expensive/small objects can be
seen
Thin sections do not need to be prepared/shows surface of specimen/can have
3-D images
cross a cell surface membrane
lipid-soluble molecules pass via phospholipid bilayer
Water moves by osmosis from high water potential to low
water potential
Active transport is movement from low to high concentration against
concentration gradient
facilitated diffusion down the concentration gradient
Alveoli walls thicken/ Less surface area/ Loss of elastin so lungs cannot recoil/air not replenished so Less
oxygen enters blood / less energy released (emphysema)
Bacteria transmitted in droplets /Bacteria ingested by phagocytes / then Bacteria is encased in nodule and is not replicating/ If immunosuppressed
bacteria replicate and go to destroy the epithelial cells Leading to scar tissue Damage so there's less diffusion/damage allows bacteria to spread to other
organs
Phagocytes engulf pathogens/Enclosed in a phagosome/Lysosomes have enzymes that digest the pathogens