4016476
Protein Kinase C
- Regulated by two mechanisms
- PHOSPHORYLATION
- Regulates the active site
and subcellular localization
of the enzyme.
- Regulates the active site
and subcellular localization
of the enzyme.
- SECOND MESSENGERS
- Promote protein kinase C's
membrane association and
resulting pseudosubstrate
exposure.
- Promote protein kinase C's
membrane association and
resulting pseudosubstrate
exposure.
- PHOSPHORYLATION
- transduces the
myriad of signals
promoting lipid
hydrolysis.
- Structure
- Comprised of an N-terminal
regulatory region and a
C-terminal catalytic region
- 11 protein kinase C isozymes have
been identified and classified into
three groups based on their structure
and cofactor regulation
- 11 protein kinase C isozymes have
been identified and classified into
three groups based on their structure
and cofactor regulation
- Comprised of an N-terminal
regulatory region and a
C-terminal catalytic region
- Function
- Enzymology
- Protein kinase C typically
phosphorylates serine or
threonine residues in
basic sequences.
- In addition to catalyzing
phosphorylation reactions,
protein kinase C has ATPase
and phosphatase activity.
- In addition to catalyzing
phosphorylation reactions,
protein kinase C has ATPase
and phosphatase activity.
- Protein kinase C typically
phosphorylates serine or
threonine residues in
basic sequences.
- Enzymology
- Biological Function
- in receptor
desensitization, in
modulating membrane
structure events, in
regulating transcription.
- in mediating immune
responses, in regulating
cell growth, and in
learning and memory.
- in receptor
desensitization, in
modulating membrane
structure events, in
regulating transcription.
- Pseudosubstrate Regulation
- Diacylglycerol and Phorbol Esters
- Phosphatidylserine
- Calcium Ions
- Substrates
- Substrates
- Calcium Ions
- Phosphatidylserine
- Diacylglycerol and Phorbol Esters
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