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Drug Metabolism

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Notes from Doctors in Training
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Mapa Mental por snlogel, atualizado more than 1 year ago
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Criado por snlogel mais de 10 anos atrás
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Resumo de Recurso

Drug Metabolism
  1. Phase I
    1. Reactions
      1. Reduction
        1. Oxidation
          1. Hydrolysis
          2. Metabolites
            1. Slightly polar
              1. Water soluble
                1. Active
              2. Phase II
                1. Reactions
                  1. Acetylation
                    1. Methylation
                      1. Sulfation
                        1. Glucuronidation
                        2. Metabolites
                          1. Very polar
                            1. Inactive
                          2. Disulfiram-like reaction
                            1. Metronidazole
                              1. Certain cephalosporins
                                1. Procarbazine
                                  1. 1st generation sulfonylureas
                                  2. Zero order kinetics
                                    1. Phenytoin
                                      1. Ethanol
                                        1. Aspirin
                                        2. TCAs
                                          1. Imipramine
                                            1. Clomipramine
                                              1. Amitriptyline
                                                1. Nortriptyline

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