49582
alzheimer's disease
- beta amyloid deposition , neurofibrillary tangles, amyloid plaques
- memory loss, cognitive impairment,depression,
loss of executive function, anosognosia(lack of
insight), loss of visuo-spatial awareness
- irritability, mood changes,psychosis, agnosia
- irritability, mood changes,psychosis, agnosia
- loss of acetyl choline
- altered macrophages gene expression -
lack of clearance of amyloid deposition by
the macrophages
- affects the hippocampus, amygdala, basal nuclei,
- risk factors - HT, DM, IHD,AF,
Relative, apolipoprotien E, smoking,
alcohol
- affects the hippocampus, amygdala, basal nuclei,
- Donezepil, rivastigmine,
galantamine
- Rivastigmine is more useful in lewy body dementia.
- SE - dizziness, dry mouth, heart
block, Arrhythmias, LFTs ^,
Peptic ulcer disease
- Rivastigmine is more useful in lewy body dementia.
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