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660858
normal haemostasis
Descrição
Paediatrics (Haematological disorders) Mapa Mental sobre normal haemostasis, criado por v.djabatey em 21-03-2014.
Sem etiquetas
haematological disorders
paediatrics
paediatrics
haematological disorders
Mapa Mental por
v.djabatey
, atualizado more than 1 year ago
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Criado por
v.djabatey
mais de 10 anos atrás
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Resumo de Recurso
normal haemostasis
haemostasis= normal process of blood clotting
occurs via a series of tightly regulated interactions
5 main components
coagulation factors
made (mainly by liver) in inactive form
activated when coagn initiated
usually by tissue factor (released by vessel injury)
coagulation inhibitors
either circulate in plasma or bound to endothelium
are necessary to prevent widespread coagn throughout the body once coagulatn has been initiated
fibrinolysis
limits fibrin deposition @ site of injury
due to activity of plasmin enzyme
platelets
vital for haemostasis
cos they aggregate at sites of vessel injury
form haemostatic plug (which is then stabilised by fibrin)
blood vessels
start and limit coagulation
intact vascular endothelium secretes prostaglandin I2 & nitric oxide
promote vasodilatatn & inhibit platelet aggregatn
damaged endothelium
releases tissue factor & procoagulants (e.g. collagen & von Willebrand factor)
has inhibitors of coagulation on endothelial surface (thrombomodulin, antithrombin & protein S)
coagulation cascade
endpoint=generation of thrombin
2 main pathways to get thrombin
intrinsic pathway
extrinsic pathway
mostly responsible for starting normal haemostasis & thrombotic disease
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