Questão 1
Questão
Which of the following is a systemic sign of infection?
Responda
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Pain
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Erythema
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Swelling
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Fatigue
Questão 2
Questão
Which of the following does NOT directly determine the virulence of a microbe?
Questão 3
Questão
The widespread necrosis of respiratory mucosa caused by an influenza infection often gives rise to:
Responda
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Subclinical infections
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Primary infections
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Secondary infections
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Tertiary infections
Questão 4
Questão
Which of the following bodily fluids would you expect to be sterile?
Responda
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Blood
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Vaginal discharge
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Faeces
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Sputum
Questão 5
Questão
That time during an infection when the infected person may experience a headache or fatigue and senses he or she is “coming down with something” is referred to as which of the following?
Responda
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Subclinical
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Acute
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Prodromal
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Incubation
Questão 6
Questão
Which of the following is a local sign of infection?
Responda
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Fever and leukocytosis
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Headache and anorexia
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Nausea, weight loss, and fatigue
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Pain, erythema, and swelling
Questão 7
Questão
What are culture and sensitivity tests used for?
Responda
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To provide a specific medium that supports maximum microbial growth
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To provide living host cells for microbes requiring such for replication
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To identify the causative microbe and the effective antimicrobial agent for it
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To determine the type of microbe present in a specimen
Questão 8
Questão
What does leukocytosis frequently indicate?
Questão 9
Questão
Secondary immune deficiencies occur because of:
Questão 10
Questão
A common symptom of individuals with immunodeficiency is:
Responda
-
Anaemia
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Recurrent infections
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Lots of allergies
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Auto antibody production
Questão 11
Questão
Primary immune deficiencies occur because of:
Questão 12
Questão
Immunodeficiencies may result in an increased risk of infections by normally harmless microorganisms. These infections are referred to as:
Responda
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transient
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pathogenic
-
opportunistic
-
virulent
Questão 13
Questão
Which of the following is an effect of cytokines? They:
Responda
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increase the rate of mitosis in tumors.
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cause immediate pain.
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activate and stimulate proliferation of B and T lymphocytes.
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destroy antigens quickly.
Questão 14
Questão
An incompatible blood transfusion is an example of this type of hypersensitivity reaction:
Responda
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Type IV
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Type III
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Type II
-
Type I
Questão 15
Questão
Reaction to latex gloves (in most cases) is an example of what type of hypersensitivity reaction:
Responda
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Type IV
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Type III
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Type II
-
Type I
Questão 16
Questão
In this type of reaction, the antigen and antibody combine forming an immune complex which then can get deposited into tissue for example the kidneys.
Responda
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Type I
-
Type II
-
Type III
-
Type IV
Questão 17
Questão
A bee sting that causes a person to go into anaphylactic shock is an example of this type of hypersensitivity reaction:
Responda
-
Type I
-
Type II
-
Type III
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Type IV
Questão 18
Questão
The first line of defense which changes very little during our lifetime is called
Responda
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Passive immunity
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Active immunity
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Adaptive immune response
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Innate immune response
Questão 19
Questão
Humoral immunity is mediated by:
Responda
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T lymphocytes (T cells).
-
B lymphocytes (B cells).
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natural killer cells.
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neutrophils.
Questão 20
Questão
Which white blood cells are responsible for adaptive immunity:
Responda
-
Monocytes
-
Eosinophils
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Neutrophils
-
Lymphocytes
Questão 21
Questão
A molecule that will stimulate the adaptive immune response:
Responda
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Antigen
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Pathogen
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Immunoglobulin
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Antibody
Questão 22
Questão 23
Questão
The role of memory cells is to:
Responda
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change into an antibody-secreting cell following activation.
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immediately secrete antibodies following the first exposure to antigen.
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recognize the antigen and stimulate the immune response.
-
bind complement to the antibody.
Questão 24
Questão
Humoral immunity is mediated by:
Responda
-
Natural killer cells
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T cells
-
B cells
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Neutrophils
Questão 25
Questão
The most abundant, actively motile, phagocytic leukocyte is the:
Responda
-
Neutrophil
-
Monocyte
-
Basophil
-
Macrophage
Questão 26
Questão
Which cells are required to process and present antigens from foreign material as the initial step in the immune response?
Responda
-
T-helper cells
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Macrophages
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Eosinophils
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Monocytes
Questão 27
Questão
The immunoglobulin that is found in tears and saliva is:
Questão 28
Questão
Exposure to peanuts where the person goes into anaphylactic shock is an example of this type of hypersensitivity reaction:
Responda
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Type III
-
Type I
-
Type II
-
Type IV
Questão 29
Questão
A common primary target for most immunosuppressant drugs is:
Responda
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B cell activation
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Macrophages
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All cytokines
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T cell activation
Questão 30
Questão
An autoimmune disease is:
Responda
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an abnormal response to ingested food and drugs
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failure of the immune system to distinguish self from nonself
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an extreme response to normally harmless material in the environment
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excessive formation of antibodies following exposure to foreign material
Questão 31
Questão
When an allergen binds with IgE antibodies on mast cells, resulting in release of chemical mediators, this reaction is called:
Questão 32
Questão
Autoimmunity arises when a breakdown in 'self-
Responda
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Specificity
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Immunity
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Memory
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Tolerance
Questão 33
Questão
A 22-year-old prostitute was recently diagnosed with HIV. A decrease in which of the following cell types would be expected to accompany this virus?
Responda
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CD8 T cells
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T memory cells
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CD4 T cells
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B cells
Questão 34
Questão
Primary immune deficiencies occur because of:
Questão 35
Questão
A 30-year-old male was diagnosed with HIV. Which of the following treatments would be effective?
Questão 36
Questão
Which type of immunity is provided by a vaccination?
Responda
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Passive natural
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Active artificial
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Active natural
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Passive artificial
Questão 37
Questão
Which of the following is NOT a cause of immunodeficiency?
Responda
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Hypoplasia of the thymus
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Immunosuppresive agents
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Atrophy of lymph nodes
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Delayed hypersensitivity
Questão 38
Questão
All of the following are factors that promote healing EXCEPT:
Responda
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Effective circulation
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Advanced age
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Good nutrition: protein, vitamins A & C
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A clean, undisturbed wound
Questão 39
Questão
A raised thickened scar that grows beyond the wound margin is
Responda
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Keloid scar
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Epithelialisation
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Ulcer
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Hypertrophic scar
Questão 40
Questão
The purpose of inflammation include all the following except:
Responda
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Eliminate/neutralise injurious agent
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To remove body toxins
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Localise injury and prevent further damage
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Clean-up tissue for healing
Questão 41
Questão
The first phagocytic cell(s) to enter a site of injury are:
Responda
-
Neutrophils
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Macrophages
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Monocytes
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Lymphocytes
Questão 42
Questão
Systemic manifestations of inflammation include all EXCEPT:
Responda
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Pyrexia
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Malaise
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Regional swelling
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Anorexia
Questão 43
Questão
Pathophysiology may be defined as the study of:
Questão 44
Questão
Glucocorticoids are produced by
Responda
-
The hypothalamus
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The spleen
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The thymus glands
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The adrenal glands
Questão 45
Questão
The mechanism of action of glucocorticoids include all of the following except:
Responda
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Inhibit of helper T cells
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Prevent the synthesis of arachidonic acid
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Increase production of antibodies
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Inhibit protein synthesis of chemical mediators
Questão 46
Questão
Which of the following effects is NOT one typically associated with glucocorticoids?
Responda
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Reduced prostaglandin sythesis
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Stimulation of fat and protein break down
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Reduced bone density
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Increased sodium and water retention
Questão 47
Questão
Patients taking glucocorticoids for long periods of time are likely to develop all of the following
Questão 48
Questão
Which of the following drugs relieves fever and some types of pain but is NOT an anti-inflammatory agent?
Responda
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Paracetamol
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Prednisone
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Asprin
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Ibuprofen
Questão 49
Questão
Drugs that have anti-inflammatory, analgesic, and antipyretic activities include:
1. COX-2 inhibitors (NSAIDs).
2. glucocorticoids (e.g., prednisone).
3. ibuprofen (NSAID).
4. paracetamol.
5. aspirin.
Questão 50
Questão
All of the following are correct statements regarding wound healing EXCEPT:
Responda
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Resolution occurs where there is minimal tissue damage and the cells can recover.
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Regeneration occurs where the cells are capable of mitosis.
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Granulation tissue forms a permanent replacement for damaged tissue.
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Scar tissue forms where the surrounding cells are incapable of mitosis
Questão 51
Questão
Which of the following factors generally WOULD NOT delay wound healing?
Questão 52
Questão
exudates are thick, yellow/green and typically indicates a bacterial infection
Responda
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Serous
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Fibrinous
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Purulent
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Haemorrhagic
Questão 53
Questão
Systemic manifestations of inflammation include all EXCEPT:
Responda
-
Pyrexia
-
Malaise
-
Regional swelling
-
Anorexia
Questão 54
Questão
Chemical mediators released during inflammatory response include:
Responda
-
Albumin and fibrinogen
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Growth factors and cell enzymes
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Histamine and prostaglandins
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Macrophages and neutrophils
Questão 55
Questão
Aetiology is defined as the study of the:
Questão 56
Questão
Identify the proper sequence in the healing process
Responda
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1)A blood clot forms; 2) granulation tissue grows into the gap; 3) new blood vessels develop; 4) phagocytosis of foreign material and cell debris occurs; 5) and collagen fibers form a tight, strong scar.
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1)Foreign material and cell debris are removed by phagocytes; 2) a blood clot forms; 3) granulation tissue grows into the gap; 4) new blood vessels form; 5) and collagen fibers grow and cross-link.
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1) A blood clot forms; 2) phagocytes remove foreign material and cell debris; 3) granulation tissue grows into the gap; 4) new blood vessels form; 5) and collagen fibers promote formation of a tight, strong scar.
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1) Collagen fibers form in the damaged area; 2) a blood clot forms; 3) granulation tissue grows into the gap; 4) angiogenesis takes place; 5) and foreign material and cell debris are removed by phagocytes.
Questão 57
Questão
To which of the following does the term apoptosis refer?
Responda
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Unplanned death of a group of cells
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Preprogrammed cell self-destruction
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Increase rate of mitosis of cells
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Necrotic tissue invaded by bacteria
Questão 58
Questão
A patient is on a high dose of glucocorticoids to treat lupus. Which of the following blood tests would a nurse be most concerned about?
Responda
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Blood glucose
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Liver enzymes
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Clotting time
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pH
Questão 59
Questão
A patient with type 1 diabetes was prescribed a glucocorticoid for chronic obstructive pulmonary disease. Which will the nurse expect in the treatment plan?
Responda
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A decrease in the amount of insulin needed
-
An increase in the amount of insulin needed
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No change in the amount of insulin needed
-
An increase in the need for carbohydrates
Questão 60
Questão
Inflammation is a non-specific response to:
Questão 61
Questão
Histamines are produced from ? and cause ?.
Responda
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Plasma proteins; increased platelet aggregation
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Mast cells; vasodilation and increased capillary permeability
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All cell membranes; pain
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Platelets; attraction of neurophils
Questão 62
Questão
A broad-spectrum bactericidal agent would be expected to:
Responda
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reduce the replication of many bacteria.
-
reduce the growth of many gram-positive and gram-negative bacteria
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destroy many gram-positive and gram-negative bacteria
-
destroy all pathogenic microbes
Questão 63
Questão
Bacterial mutation means that:
Responda
-
pathogens become nonpathogens
-
the host's immune response to that bacteria is strengthened
-
the bacteria survives adverse conditions but can no longer replicate
-
its genetic information has changed
Questão 64
Responda
-
is the capacity of microbes to cause disease/infection
-
is the size of a specific microbe
-
is the presence of toxins in the blood
-
is the presence of viruses in the blood
Questão 65
Responda
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are very heat tolerant
-
may cause fever and fatigue
-
can disrupt cellular metabolic and signalling processes causing widespread damage
-
can be incorporated into the structure of the cell membrane as liposaccharides
Questão 66
Questão
Gram negative bacteria have
Responda
-
A thick peptidoglycan layer cell wall
-
A thin peptidoglycan cell wall sandwiched between an inner cytoplasmic cell membrane and a bacterial outer membrane.
-
No cell wall only a thick cell membrane
-
require oxygen as a source of energy and therefore for growth.
Questão 67
Responda
-
are multicellular organisms
-
have intricate life cycles including egg, larvae and adults stages
-
replicate asexually by cell division
-
all of the answers are correct
Questão 68
Questão
Opportunistic infections are:
Responda
-
An infection by a non-pathogenic organism that has become pathogenic
-
The capacity of microbes to cause disease
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Presence and multiplication of micro-organisms that is not yet causing disease
-
An organism participating in a symbiotic relationship with the host
Questão 69
Questão
What is a eukaryotic organism, that contains both a cell wall and cell membrane. When they cause an infection it is termed mycosis
Responda
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Fungi
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Virus
-
Bacteria
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Protozoa
Questão 70
Questão
Which of the following factors would NOT increase the virulence of a specific microbe?
Questão 71
Questão
Triazole as an antifungal agent works by:
Responda
-
Disrupt the synthesis of its cell membrane
-
Disrupt DNA replication
-
Disrupt the synthesis of its cell wall
-
Inhibit hydrogen peroxide metabolism
Questão 72
Questão
An antimicrobial agent with a narrow spectrum of activity reflects a drug that has:
Responda
-
only a weak antibiotic action.
-
effectiveness against a relatively small variety of microbes.
-
a low potency.
-
a narrow margin of safety.
Questão 73
Questão
Which of the following signs would best indicate a bacterial infection (in comparison to a viral infection)?
Responda
-
The presence of pain
-
The presence of purelent exudate.
-
The presence of a serous exudate.
-
The presence of swelling.
Questão 74
Questão
During which period is the infectious disease fully developed?
Responda
-
Prodromal
-
Acute
-
Incubation
-
Aggresive
Questão 75
Questão
The structure of a virus includes:
Responda
-
a cell wall and membrane
-
metabolic enzymes and a cell wall
-
a protein coat and either DNA or RNA
-
a slime capsule and cilia
Questão 76
Questão 77
Questão
Bacterial mutation means that:
Responda
-
pathogens become nonpathogens
-
the bacteria survives adverse conditions but can no longer replicate
-
its genetic information has changed
-
the host's immune response to that bacteria is strengthened
Questão 78
Questão
Which of the following mechanisms is NOT one of the four typical mechanisms of action of antibiotic agents
Responda
-
Affect bacterial folic acid synthesis
-
Inhibit bacterial DNA synthesis
-
Disrupt bacterial meiosis
-
Disrupt cell wall synthesis
Questão 79
Questão
Which of the following clinical manifestations is not one typically associated with anaphylaxis
Responda
-
Pruritus
-
Hypertension
-
Stridor
-
Syncopy
Questão 80
Questão
Which of the following is NOT a cause of immunodeficiency?
Responda
-
Atrophy of lymph nodes
-
Immunosuppresive agents
-
Hypoplasia of the thymus
-
Delayed hypersensitivity
Questão 81
Questão
Primary immune deficiencies occur as a result of:
Responda
-
A genetic defect affecting immune cell number
-
Human immunodeficiency virus
-
Excessive emotional stress
-
Lack of vitamin C
Questão 82
Questão
An example of a live attenuated vaccine includes:
Questão 83
Questão
The main property of the adaptive immune response for immunity to previously encountered infections is:
Questão 84
Questão
The role of memory cells is to
Responda
-
change into an antibody-secreting cell following activation.
-
immediately secrete antibodies following the first exposure to antigen.
-
recognize the antigen and stimulate an immune response.
-
activate the hippocampus in the CNS
Questão 85
Questão
White blood cells responsible for adaptive immunity:
Responda
-
Neutrophils
-
Lymphocytes
-
Monocytes
-
Eosinophils
Questão 86
Questão
Which cells are required to process and present antigens from foreign material as the initial step in the immune response?
Responda
-
T-helper cells
-
Macrophages
-
Eosinophils
-
Mast cells
Questão 87
Questão
A common primary target for most immunosuppressant drugs is:
Questão 88
Questão
Some common treatments for immunodeficiency may include marrow or thymus transplants and:
Responda
-
Hyperbaric treatments
-
Blood transfusions and narrow spectrum antibiotics
-
Prophylactic antibiotics and cytokine stimulants
-
Antibiotics and radiation therapy
Questão 89
Questão
Interferons work by:
Responda
-
Suppress viral replication in infected cells
-
Stimulates cytokine production
-
Inhibit macrophage activity
-
Inducing fever
Questão 90
Questão
The immune system identifies foreign organisms via the recognition of surface:
Responda
-
antigens
-
cytokines
-
interferons
-
antibodies
Questão 91
Questão
Type 1 diabetes mellitus is associated with a:
Responda
-
Type III hypersensitivity reaction
-
Type II hypersensitivity reaction
-
Type IV hypersensitivity reaction
-
Type I hypersensitivity reaction
Questão 92
Questão
Systemic lupus erythematosus is caused by:
Responda
-
development of an immune-deficient state.
-
a chronic allergic condition.
-
immune complex deposits of anti DNA/RNA antibodies.
-
a deficiency of T lymphocytes.
Questão 93
Questão
The type of white blood cells that contains chemical mediators and plays an important part in allergic inflammatory responses is the:
Responda
-
Basophil
-
Neutrophil
-
Monocyte
-
Macrophage
Questão 94
Questão
The common local effects of an expanding tumour mass include:
1. obstruction of a tube or duct.
2. anemia and weight loss.
3. cell necrosis and ulceration.
4. tumour markers in the circulation.
Questão 95
Questão
Which of the following does paraneoplastic syndrome refer to?
Responda
-
The decreased resistance to infection resulting from malignant tumors
-
The effects of substances such as hormones secreted by the tumor cells
-
The effects of multiple metastatic tumors
-
Severe weight loss and cachexia associated with advanced cancer
Questão 96
Questão
Ultraviolet light is considered a carcinogen because:
Responda
-
It produces a carcinogenic enzyme in skin cells
-
It introduces errors into DNA (genes)
-
It directly prevents telomere shortening
-
It directly prevents DNA repair
Questão 97
Questão
First line treatment for testicular cancer always involves
Responda
-
nodulectomy
-
chemotherapy
-
radiation
-
orchidectomy
Questão 98
Questão
Staging systems used to classify a malignant tumour at the time of diagnosis are based on which of the following factors?
Responda
-
Size, encapsulated or non-encapsulated, invasion into neighboring tissue
-
Size of the tumour, involvement of lymph nodes, metastases
-
Location of tumour, size, type of cellular abnormality
-
Type of cellular abnormality, size of secondary tumours, location/tissue affected
Questão 99
Questão
Why is a patient with prostate cancer prescribed an estrogen?
Responda
-
To soften prostatic tissue
-
To decrease the rate of replication for malignant cells
-
To achieve hormonal balance
-
To suppress prostate gland function
Questão 100
Questão
Seeding refers to:
Responda
-
Spread of cancer cells in body cavities/membranes
-
Spread of cancer cells into the nearest lymph node
-
Local spread of cancer cells within a tissue
-
Spread of cancer cells to distant sites in the body by blood or lymph