Questão 1
Questão
WHICH OF THESE LISTS CONTAINS ONLY MONOSACCHARIDES?
Responda
-
Glucose, galactose, fructose
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Sucrose, lactose, mannose
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Glucose, galactose, lactose
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Glucose, galactose, sucrose
Questão 2
Questão
STARCH IS SYNTHESISED BY:
Responda
-
Plants
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Insects
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Cancer cells
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All of the above
Questão 3
Questão
WHICH FUNCTIONAL GROUPS ARE PRESENT IN THE STRAIGHT CHAIN FORM OF FRUCTOSE?
Responda
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Aldehyde and amine
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Amine and ketone
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Ketone and alcohol
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Amine and alcohol
Questão 4
Questão
FOR EACH MOLECULE OF GLUCOSE, WHAT IS THE NET GAIN OF ATP IN GLYCOLYSIS?
Responda
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No molecules
-
2 molecules
-
4 molecules
-
8 molecules
Questão 5
Questão
A DISEASE IS CAUSED BY MUTATIONS IN THE GENES ENCODING ENZYMES IN THE LELOIR PATHWAY. WHICH SUGAR WILL PATIENTS BE UNABLE TO METABOLISE?
Responda
-
Glucose
-
Galactose
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Fructose
-
Mannose
Questão 6
Questão
PERIPHERAL MEMBRANE PROTEINS ARE:
Responda
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Associated with integral membrane proteins
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Covalently linked to lipid molecules
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Always glycosylated
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Inserted into the membrane such that they have residues exposed on both sides
Questão 7
Questão
THE STRUCTURE AND FUNCTION OF A METABOLIC ENZYME IS LIKELY TO BE:
Responda
-
Very different, even in closely related organisms
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Similar in different mammals, but different between mammals and the bacteria living in their guts
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Similar in all animals, but different in plants
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Highly conserved through evolution by natural selection
Questão 8
Questão
THE CALVIN CYCLE (“DARK” REACTIONS OF PHOTOSYNTHESIS):
Responda
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Uses sucrose and NADPH
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Generates sucrose and NADPH
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Uses sucrose and generates NADPH
-
Generates sucrose and uses NADPH
Questão 9
Questão
A SATURATED FATTY ACID WITH 18 CARBONS WILL BE OXIDISED BY β-OXIDATION TO GIVE:
Questão 10
Questão
WHICH OF THESE FATTY ACIDS IS LIKELY TO HAVE THE LOWEST MELTING TEMPERATURE?
Responda
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An 18 carbon saturated fatty acid
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An 18 carbon fatty acid with one double bond
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A 16 carbon saturated fatty acid
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A 16 carbon fatty acid with two double bonds
Questão 11
Questão
THE SUGAR RESIDUE IN ATP IS:
Responda
-
Ribose
-
Deoxyribose
-
Ribulose
-
Raffinose
Questão 12
Questão
THE CONVERSION OF GLYCERALDEHYDE 3-PHOSPHATE TO 1,3-BISPHOSPHOGLYCERATE IN GLYCOLYSIS REQUIRES:
Questão 13
Questão
IN MAMMALIAN CELLS UNDER ANAEROBIC CONDITIONS, THE CONVERSION OF PYRUVATE TO LACTATE REGENERATES WHICH MOLECULE?
Questão 14
Questão
CONSIDER GLYCOLYSIS AND THE KREBS’ TRICARBOXYLIC ACID CYCLE TOGETHER. WHICH IS THE FIRST STEP WHICH RELEASES CARBON DIOXIDE?
Responda
-
Fructose 1,6-bisphosphate → Glyceraldehyde 3-phosphate + dihydroxyacetone phosphate
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Pyruvate → Acetyl Coenzyme A
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Citrate → Isocitrate
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Isocitrate → α-ketoglutarate
Questão 15
Questão
THE DECARBOXYLATION OF ISOCITRATE TO PRODUCE α-KETOGLUTARATE IN THE KREBS’ TRICARBOXYLIC ACID CYCLE REQUIRES:
Questão 16
Questão
THE SEQUENCE OF REACTIONS OXIDATION-HYDRATION-OXIDATION OCCURS IN WHICH TWO METABOLIC PATHWAYS?
Responda
-
Glycolysis and the Krebs’ tricarboxylic acid cycle
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Fatty acid oxidation and glycolysis
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Fatty acid oxidation and the Krebs’ tricarboxylic acid cycle
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Fatty acid oxidation and the Leloir pathway
Questão 17
Questão
THE REACTION: PYRUVATE + CARBON DIOXIDE + ATP → OXALOACETATE + ADP + PI, WHICH IS CATALYSED BY THE ENZYME PYRUVATE CARBOXYLASE IS IMPORTANT IN WHICH TWO PROCESSES?
Responda
-
Replenishing the Krebs tricarboxylic acid cycle intermediates and gluconeogenesis
-
Glycolysis and gluconeogenesis
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Gluconeogenesis and glycogen synthesis
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Replenishing the Krebs tricarboxylic acid cycle intermediates and glycolysis
Questão 18
Questão
IN BIOCHEMICAL PATHWAYS THE PRECURSORS ARE:
Responda
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Compounds which occur at cross-over or branching points in metabolic pathways
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Initial substrates which feed into metabolic pathways
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Compounds which catalyse the individual steps in a metabolic pathway
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Metabolic hubs which allow the use and re-use of relatively small numbers of molecules
Questão 19
Questão
PROTEIN BIOSYNTHESIS CYCLE IS AN EXAMPLE OF WHICH TYPE OF BIOCHEMICAL PATHWAY?
Responda
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Anabolic
-
Catabolic
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Amphibolic
-
Hyperbolic
Questão 20
Questão
WHICH OF THE FOLLOWING IS TRUE OF ENDOTHERMS?
Responda
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They generate most of their heat through internal processes
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They get most of their heat from the environment
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They generate most of their heat from external processes
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They cannot regulate their body temperature
Questão 21
Questão
PARATHYROID HORMONE HELPS REGULATE:
Responda
-
Body fluids
-
Blood calcium
-
Body temperature
-
Breathing
Questão 22
Questão
A COMMON MECHANISM FOR INHIBITING METABOLIC PATHWAYS IS:
Questão 23
Questão
FRUCTOSE 2,6-BISPHOSPHATE:
Responda
-
Activates fructose bisphosphatase-1
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Activates phosphofructokinase-1
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Inhibits phosphofructokinase-2
-
Activates phosphofructokinase-2
Questão 24
Questão
ANAEROBIC MUSCLE CELLS PRODUCE LACTIC ACID TO RECYCLE:
Responda
-
NADH to NAD+ via the action of lactate dehydrogenase
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NADH to NAD+ via the action of alcohol dehydrogenase
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NAD+ to NADH via the action of lactate dehydrogenase
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NAD+ to NADH via the action of alcohol dehydrogenase
Questão 25
Questão
OXYGENATION OF ANAEROBIC YEAST CULTURE INDUCES THE "PASTEUR EFFECT", WHICH IS CAUSED BY:
Responda
-
Allosteric inhibition of phosphofructokinase-1 by increased AMP levels
-
Allosteric inhibition of fructose 1,6-bisphosphatase by increased ATP levels
-
Allosteric inhibition of phosphofructokinase-1 by increased ATP levels
-
Allosteric stimulation of phosphofructokinase-1 by increased AMP levels
Questão 26
Responda
-
An activator of pyruvate kinase
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An activator of protein kinase A
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The product of adenylate kinase
-
An activator of phosphofructokinase-1
Questão 27
Questão
CANCER CELLS PRODUCE LARGE AMOUNTS OF LACTATE EVEN IN THE PRESENCE OF OXYGEN BECAUSE THEY:
Responda
-
Lack mitochondria
-
Lack the gene for citrate synthase
-
Possess an over-active glycerol phosphate shuttle
-
Have a defective glycerol phosphate shuttle
Questão 28
Questão
WHEN CONSIDERING ENZYME CATALYTIC MECHANISMS, ACID-BASE CATALYSIS IS USUALLY DEPENDANT UPON:
Responda
-
Hydrogen bonding with at least one amino acid side chain at the active site to facilitate formation of the transition state.
-
Hydrogen bonding between the carbonyl and amide groups of peptide bonds to facilitate formation of the transition state.
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Hydrogen bonding between a water molecule and the substrate to facilitate formation of the transition state.
-
Hydrogen bonding with an oxidised metal ion prosthetic group in the active site to facilitate formation of the transition state.
Questão 29
Questão
MULTIPLICATION OF UBIQUITIN TAGGING:
Responda
-
Inhibits proteosome-mediated protein degradation
-
Is essential for proteosome-mediated protein degradation
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Enhances proteosome-mediated protein degradation
-
Has nothing to do with proteosome-mediated protein degradation
Questão 30
Questão
ENZYMES REDUCE THE:
Responda
-
Entropy associated with chemical reactions
-
Enthalpy associated with chemical reactions
-
Gibb’s free energy associated with chemical reactions
-
Activation energy associated with chemical reactions
Questão 31
Questão
THE TRANSITION STATE IN AN ENZYME-CATALYSED REACTION:
Responda
-
Is always covalently associated with the enzyme.
-
Is never covalently associated with the enzyme.
-
Can never be observed experimentally.
-
Can often be similar in structure to potent enzyme inhibitors.
Questão 32
Questão
THE ALANINE CYCLE:
Responda
-
Is completely located in the mitochondrial matrix.
-
Facilitates transport of ammonia produced in the liver to the muscles where it can be used in anabolic processes - preventing the exposure of free ammonium to other components of eukaryote tissues.
-
Facilitates transport of ammonia produced in the muscles to the liver where it can be effectively removed from the body - preventing the exposure of free ammonium to other components of eukaryote tissues.
-
Is completely located in the cytoplasm of the cell – preventing the exposure of free ammonium to other components of eukaryote tissues.
Questão 33
Questão
KOSHLAND’S INDUCED FIT MODEL FOR ENZYME-SUBSTRATE COMPLEX FORMATION MAY EXPLAIN WHY:
Responda
-
Enzymes have particular substrate specificity.
-
Enzymes are able to catalyse chemical reactions that cannot be facilitated in any other way
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Enzymes increase the rate of a reaction by reduction of the activation energy change for the reaction
-
Enzymes can effectively reduce the loss of energy from a chemical reaction as heat
Questão 34
Questão
IN ENZYME CATALYSIS THE TERM “APPROXIMATION” REFERS TO:
Responda
-
A catalytic strategy that facilitates transition state stabilisation through formation of covalent bonds between a substrate and amino acid groups in the active site
-
A catalytic strategy that facilitates transition state stabilisation through formation of hydrogen bonds and electrostatic interactions between a substrate and amino acid groups in the active site
-
A catalytic strategy that facilitates transition state stabilisation through interaction with metal ions in the active site
-
A catalytic strategy that facilitates transition state stabilisation through direct transfer of a proton to the substrate from an acidic amino acid group in the active site
Questão 35
Questão
AN OXYANION HOLE IS:
Responda
-
A region of the enzyme active site that facilitates binding of positively charged substrates through their association with oxygen-containing amino-acid side chains in the enzyme.
-
A region of the enzyme active site that facilitates binding of negatively charged substrates through their association with oxygen-containing amino-acid side chains in the enzyme.
-
A region of the active site that facilitates binding of positively charged oxygen-containing groups present in a substrate.
-
A region of the active site that facilitates binding of negatively charged oxygen-containing groups present in a substrate.
Questão 36
Questão
IF THE ΔG°' OF THE REACTION A → B is –20 kJ/mol, WHAT WILL HAPPEN IN THE PRESENCE OF A SPECIFIC ENZYME UNDER STANDARD CONDITIONS?
Responda
-
The reaction will stop
-
The reaction will proceed spontaneously from B to A
-
The reaction will proceed spontaneously from A to B
-
The reaction will not occur spontaneously
Questão 37
Questão
WHICH OF THE FOLLOWING IS AN EXERGONIC PROCESS?
Questão 38
Questão
FOR THE FOLLOWING REACTION:
L-Malate + NAD+ → Oxaloacetate + NADH + H+ ΔG°' = +29.7 kJ/mol.
WHICH OF THE FOLLOWING STATEMENTS IS CORRECT?
Responda
-
This reaction can only occur in a cell in which NADH is converted to NAD+ by the respiratory chain
-
This reaction can only occur in a cell if it is coupled to another reaction for which ΔG°' is large and negative
-
This reaction may occur in cells at some concentrations of substrate and product
-
This reaction is energy-releasing
Questão 39
Questão
WHICH OF THE FOLLOWING STATEMENTS ABOUT MIDPOINT REDOX POTENTIALS IS INCORRECT?
Responda
-
Redox potentials can be used to calculate free energy changes
-
Redox potential is measured in volts
-
Oxygen reduction has the highest potential
-
The strongest oxidants have the most negative potential
Questão 40
Questão
WHICH OF THE FOLLOWING REDOX COUPLE HAVE THE HIGHEST MIDPOINT REDOX POTENTIAL?