Protein Structure Pt. 1

Descrição

Structural Basis for Biological Function (Basics) Quiz sobre Protein Structure Pt. 1, criado por gina_evans0312 em 21-09-2013.
gina_evans0312
Quiz por gina_evans0312, atualizado more than 1 year ago
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Criado por gina_evans0312 mais de 11 anos atrás
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Resumo de Recurso

Questão 1

Questão
Which type of protein is conjugated?
Responda
  • One that contains only amino acid residues
  • One that contains prosthetic groups
  • One that is bound to a membrane

Questão 2

Questão
Which of the following means a protein with two identical subunits?
Responda
  • Heteromultimer
  • Homomonomer
  • Homomultimer

Questão 3

Questão
Which of the following proteins types tend to have various roles, as opposed to a single, defined one?
Responda
  • Fibrous
  • Globular
  • Membrane

Questão 4

Questão
Which of the following tend not to be water soluble?
Responda
  • Fibrous
  • Globular
  • Membrane spanning

Questão 5

Questão
What secondary structures tend to make up fibrous proteins?
Responda
  • Long strands
  • Long sheets
  • Short strands

Questão 6

Questão
What is specific about the membrane spanning part of membrane proteins?
Responda
  • They are hydrophobic
  • They are hydrophillic

Questão 7

Questão
Define 'Domain' in reference to protein structure
Responda
  • Independent folding units of the tertiary structure that have independent functions
  • Independent folding units of tertiary structure that have related functions
  • Dependent folding units of secondary structure that have relation functions
  • Dependent folding units of tertiary structure that have related functions

Questão 8

Questão
Define subunit
Responda
  • Independent structures in a quaternary structure
  • Independent structures in a tertiary structure
  • Dependent subunits in a quaternary structure

Questão 9

Questão
What can be the result of a single amino acid mutation in collagen?
Responda
  • Osteoarthritis
  • Osteogenesis imperfecta
  • Osteocalcification

Questão 10

Questão
What is Resonance (as pertaining to protein structure)?
Responda
  • Where bond pairs cannot be described as a single Lewis Diagram
  • Where two atoms in separate molecules cause each other to vibrate
  • Where two atoms in separate molecules are more likely to bond to each other than to another atom

Questão 11

Questão
Which is the psi bond?
Responda
  • Between the carbonyl carbon and the alpha carbon
  • Between the alpha carbon and the amide group
  • Between the alpha carbon and the R group

Questão 12

Questão
Which is the phi bond?
Responda
  • Between the alpha carbon and the amide group
  • Between the alpha carbon and the carbonyl carbon
  • Between the alpha carbon and the R group

Questão 13

Questão
What is Steric clashing?
Responda
  • Where the charge of an atom prevents it from being close to another
  • Where the electron arrangement of an atom prevents it from being close to another
  • Where the size of an atom prevents it from being close to another

Questão 14

Questão
Why is a peptide bond planar?
Responda
  • It has a double bond like structure
  • It's electrons clash with that of the psi bond
  • It's electrons clash with the phi bond

Questão 15

Questão
How many residues per turn in an alpha helix?
Responda
  • 3.4
  • 3.5
  • 3.6

Questão 16

Questão
How much does an alpha helix rise per aa?
Responda
  • 1.5 angstroms
  • 1.6 angstroms
  • 1.7 angstroms

Questão 17

Questão
Alpha helices are stabilised by hydrogen bonding with what groups?
Responda
  • Carbonyl oxygen 4 amino acids away
  • Carbonyl oxygen 6 amino acids away
  • Carbonyl oxygen 8 amino acids away

Questão 18

Questão
The stabilising effect of the hydrogen bonds makes a loop of how many atoms?
Responda
  • 12
  • 13
  • 14

Questão 19

Questão
Which of the following destabilize an alpha helix?
Responda
  • Glycine
  • Proline
  • Leucine
  • Glutamic acid

Questão 20

Questão
Beta sheets rise by 3.47A per residue in anti-parallel sheets
Responda
  • True
  • False

Questão 21

Questão
In parallel sheets, there is a rise of .... per residue
Responda
  • 3.25A
  • 4.25A
  • 2.25A

Questão 22

Questão
3 residues per turn of the strand are pictured as a helix
Responda
  • True
  • False

Questão 23

Questão
Anti-parallel strands are _ stable than parallel ones
Responda
  • More
  • Less

Questão 24

Questão
Side chains all point the same way (in the plane of the sheet)
Responda
  • True
  • False

Questão 25

Questão
What is the role of loops?
Responda
  • Connecting alpha and beta sheets
  • Connecting alpha helices and alpha helices
  • Connecting beta sheets and beta sheets

Questão 26

Questão
Loops contain mostly hydrophillic residues & are found on the protein surface
Responda
  • True
  • False

Questão 27

Questão
What is the role of beta turns?
Responda
  • To allow beta sheets to reverse direction
  • To connect beta sheets together
  • To link protein subunits together

Questão 28

Questão
What two amino acids cannot be contained within a beta sheet?
Responda
  • Proline
  • Argenine
  • Glycine
  • Valine

Questão 29

Questão
Beta turns link the oxygen of the carbonyl group and the hydrogen of the nitrile group 4 residues away
Responda
  • True
  • False

Questão 30

Questão
Levinthals Paradox- if a protein folded by trying each fold in a sequence, it would take an impossibly long time to fold correctly. Therefore, protein folding cannot be random or sequential
Responda
  • True
  • False

Questão 31

Questão
What is this?
Responda
  • The energy change as proteins fold
  • Gibbs free energy
  • Entropy change

Questão 32

Questão
Why are the internal interactions of protein folding unfavorable?
Responda
  • It decreases entropy
  • They're hydrophobic in a hydrophillic environment
  • They prevent the protein from folding correctly

Questão 33

Questão
Non-covalent and hydrophobic effects (which effects free water) decrease enthalpy
Responda
  • True
  • False

Questão 34

Questão
Change in energy during folding = Internal interactions - (Hydrophobic effect + conformational entropy)
Responda
  • True
  • False

Questão 35

Questão
Proteins fold towards configurations with the...
Responda
  • lowest energy
  • Highest energy
  • Easiest energy to reach (energy closest to that of unfolded protein)

Questão 36

Questão
What can slow the progress of protein folding?
Responda
  • A local low energy minimum
  • A local high energy minimum

Questão 37

Questão
What is nucleation?
Responda
  • Reversible secondary structure formation
  • Reversible tertiary structure formation
  • Reversible quaternary structure formation

Questão 38

Questão
Which of the following happens after nucleation?
Responda
  • The secondary structure aggregation forms a molten globular intermediate
  • Domains adjust to the lowest energy form

Questão 39

Questão
The protein is capable of conformational change after forming
Responda
  • True
  • False

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