2679692
Descrição
Quiz por Becca Shaw, atualizado more than 1 year ago
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Criado por Becca Shaw
mais de 9 anos atrás
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|
Questão 1
Questão
Drugs are evenly distributed around the body. True or false?
Responda
- True
- False
Questão 2
Questão
Irreversible binding is mainly confined to what?
Responda
-
Receptor binding sites
-
Ion channels
-
Enzyme inhibitors
-
Transport/carrier proteins
Questão 3
Questão
Irreversible binding uses what type of bonding?
Responda
-
Covalent
-
Hydrogen
-
Ionic
-
Van der Waals
Questão 4
Questão
Which of the following are examples of natural binding sites?
Responda
-
Receptor binding sites
-
Modulatory sites
-
Allosteric sites
-
Enzyme active sites
Questão 5
Questão
Modulatory or allosteric sites are a type of separate site to which drugs can bind. True or false?
Responda
- True
- False
Questão 6
Questão
Drugs that block function are known as
Responda
-
Antagonists at receptors
-
Inhibitors at transporters/carriers
-
Blockers at ion channels
-
Inhibitors at enymes
Questão 7
Questão
What is the generic name for Adrenaline?
Responda
-
Fluoxetine
-
Noradrenaline
-
Epinephrine
-
Tetracycline
Questão 8
Questão
What is the generic name for Aspirin?
Responda
-
Mefanamic acid
-
Epinephrine
-
Diacetylmorphine
-
Acetylsalicylic acid
Questão 9
Questão
What is the generic name for Heroin?
Responda
-
Fluoxetine
-
Diacetylmorphine
-
Epinephrine
-
Acetylsalicylic acid
Questão 10
Questão
What is the generic name for Prozac?
Responda
-
Fluoxetine
-
Diacetylmorphine
-
Acetylsalicylic acid
-
Mefanamic acid
Questão 11
Questão
The use of an antagonist on a receptor results in
Responda
-
Enzyme activition
-
Opening of ion channels
-
No effect produced
-
Blockage of endognous mediators
Questão 12
Questão
What direct mechanism would an agonist have on a receptor molecule?
Responda
-
Enzyme activation or inhibition
-
Opening or closing of ion channels
-
Modulation of ion channels
-
DNA transcription
Questão 13
Questão
What transduction mechanisms may occur due to the activity of an agonist on a receptor molecule?
Responda
-
Ion channel modulation
-
DNA transcription
-
Enzyme inhibition or activation
-
Opening or closing of ion channel
Questão 14
Questão
Proteins that bind to specific molecules, called ligands, to produce a response are known as receptors. True or false?
Responda
- True
- False
Questão 15
Questão
When drugs act through receptors, these receptors will always have exogenous ligands. True or false?
Responda
- True
- False
Questão 16
Questão
Examples of endogenous ligands are
Responda
-
Hormones
-
Diacetylmorphine
-
Fluoxetine
-
Neurotransmitters
Questão 17
Questão
The endogenous ligand is always an agonist. True or false?
Responda
- True
- False
Questão 18
Questão
In the absence of ligands, receptors have no other function. True or false?
Responda
- True
- False
Questão 19
Questão
Where are most receptors found?
Responda
-
Embedded in the plasma membrane
-
Circulating in the blood
-
Lining the epithelium of the gut
-
In the brain
Questão 20
Questão
Which of the following statements are true regarding antagonists?
Responda
-
They bind loosely to receptors
-
The produce no effect themselves
-
They prevent agonists from binding
-
The block the response
Questão 21
Questão
Which of the following statements is false regarding Histamine?
Responda
-
It is an endogenous agonist
-
Binds to receptors on stomach parietal cells
-
Is an exogenous agonist
-
Causes release of gastric acid
Questão 22
Questão
Which of the following blocks the parietal histamine receptors?
Responda
-
Fluoxetine
-
Acetylcholine
-
Epinephrine
-
Ranitidine
Questão 23
Questão
Histamine receptor H1 mediates which effect on the gastrointestinal tract?
Responda
-
Inflammation
-
Bile secretion
-
Smooth muscle contraction
-
Gastric acid secretion
Questão 24
Questão
Histamine receptor H2 mediates which effect on the gastrointestinal tract?
Responda
-
Inflammation
-
Secretion of gastric acid
-
Bile secretion
-
Smooth muscle contraction
Questão 25
Questão
Which anatagonist acts upon Histamine receptor H2 to prevent secretion of gastric acid?
Responda
-
Ranitidine
-
Epinephrine
-
Acetylsalicylic acid
-
Mepyramine
Questão 26
Questão
Which antagonist acts upon Histamine receptor H1 to prevent contraction of smooth muscle in parietal cells?
Responda
-
Epinephrine
-
Ranitidine
-
Mepyramine
-
Fluoxetine
Questão 27
Questão
Different receptors for the same endogenous agonist are called subtypes. True or false?
Responda
- True
- False
Questão 28
Questão
Which of the following are a type of receptor family?
Responda
-
Ionotropic receptors (ligand-gated ion channels)
-
Kinase-linked receptors
-
Nuclear receptor (cytoplasmic)
-
Metabotropic receptors (G-protein coupled receptors)
Questão 29
Questão
Which of the following statements are true concerning ionotropic receptors?
Responda
-
Channel formed from 3-5 subunits
-
Pore domain of each subunit forms a hydrophobic channel
-
Ligands bind to an intracellular domain
-
Ions flow selectively through the membrane
Questão 30
Questão
The following is typical of the mechanism of receptors incorporating ion channels: 1. Agonist binds to receptor 2. Change in ion concentration in the cell 3. Depolarisation or hyperpolarisation occurs 4. Cellular effects (response)
Responda
- True
- False
Questão 31
Questão
Nicotinic acetylcholine receptor is a part of the ionotrophic receptor family. True or false?
Responda
- True
- False
Questão 32
Questão
Which of the following statements is false regarding Metabotropic receptors? (G-protein coupled receptors)
Responda
-
Consists of a single polypeptide
-
7 transmembrane domains
-
Domains consist of beta helices
-
Ligand binds either to extracellular domain or within transmembrane domain
Questão 33
Questão
Muscarinic acetylcholine receptors are in the family of metabotropic receptors. True or false?
Responda
- True
- False
Questão 34
Questão
Alpha and beta adrenoceptors are examples of the 2nd messenger effects of GCPRs. True or false?
Responda
- True
- False
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