3126972
Questão 1
Questão
All of the following are correctly matched except?
Responda
-
Type I HSR - IgE mediated
-
Type II HSR - IgA mediated
-
Type III HSR - Immune complex - IgG mediated
-
Type IV HSR - Cell mediated
Questão 2
Questão
All of the following are true about hygiene hypothesis except
Responda
-
Excessive hygeine
-
Overuse of antibiotics
-
Not vaccinating the child
Questão 3
Questão
All of the following are components of a typical adaptive response to an helminthic infection except
Responda
-
CDH4 Th1 cells
-
Cytokines - IL 3,4,5,9,10,13
-
antibodies IgE and IgG 1 and 4
-
Effector cells such as eosinophils, basophils and mast cells
Questão 4
Questão
The main components of type I HSR are neutrophils and lymphocytes
Responda
- True
- False
Questão 5
Questão
Sensitization to antigen involves class switching to IgE production on first contact with an allergen
Responda
- True
- False
Questão 6
Questão
All of the following are stages in HSR I except
Responda
-
Initial exposure to immunogen which results in the production of reactive B and T cells - no symptoms
-
B cell - T cell interaction - antigen activation of Th2 cells
-
Production of IL 4 + IL 13
-
Production of IgE
-
Binding of IgE to Fc Epsilon Receptor and activation/sensitization of mast cell and release of mediators
-
None of the above
Questão 7
Questão
The following is true about HSR I immediate and late response
Responda
-
Within minutes mast cell + Basophils will release histamine and serotonin causing wheal and flare
-
In hours Eosinophils +Th2 will release second wave of mediators prostaglandis and leukotrienes
-
Both are correct
-
None of the above
Questão 8
Questão
Intrinsic asthma is Type I HSR reaction
Responda
- True
- False
Questão 9
Questão
The Primary method for diagnosing HSR I is by skin testing, with the characteristic response being "wheal and flare" reaction within minutes
Responda
- True
- False
Questão 10
Questão
RAST detects IgG anti-allergen in patient's serum
Responda
- True
- False
Questão 11
Questão
All of the following are used as treatment strategies for HSR I
Responda
-
Allergen avoidance
-
Correct Th1/Th2 imbalance (not clinically feasible)
-
Block mediators either with antihistamine, lipoxygenase inhibition or steroid use
-
Correct isotype switch to IgE
-
Prevent IgE binding to mast cells to prevent IgE mediated degranulation
Questão 12
Questão
Epinephrine is the main treatment for anaphylaxis - true or false
Responda
- True
- False
Questão 13
Questão
In desensitization treatment the allergen binds to IgG thereby preventing IgE mediated response - true or false
Responda
- True
- False
Questão 14
Questão
Omalizumab is a mab that binds to Fc region of IgE thereby blocking the arming of mast cells - true or false
Responda
- True
- False
Questão 15
Questão
All of the following are true about HSR II except
Responda
-
HSR II is mediated by IgG or IgM not IgE
-
HSR II the antibodies bind to the self antigen on cell membranes and extracellular matrix
-
HSR II makes autoreactive antibodies
-
HSR II activates the alternate complement pathway
Questão 16
Questão
All of the following are mechanisms for cell damage in HSR II except?
Responda
-
recruitment of neutrophils - causing tissue injury and inflammation
-
Opsonization and Phagocytosis
-
Interfere with cellular functions - either block or stimulate cell receptors
-
All of the above
-
None of the above
Questão 17
Questão
All of the following are HSR II reactions except
Responda
-
Hemolytic disease of the newborn
-
Blood transfusion reactions
-
Penicillin reaction
-
Extrinsic asthma
Questão 18
Questão
All of the following are true regarding Hemolytic disease of the newborn (HDNB) except
Responda
-
Seen when mother is Rh+ and baby is Rh-
-
Mother is O type blood group and baby A,B or AB
-
Prevention is by giving Rhogam to the mother
-
None of the above
Questão 19
Questão
All of the following are non cytotoxic type II HSR diseases except
Responda
-
Myasthenia gravis
-
NDIIM
-
Graves disease
-
Pernicious anemia
-
Penicillin allergy
Questão 20
Questão
All of the following are cytotoxic HSR II except?
Responda
-
Erythroblastosis fetalis (Hemolytic disease of the newborn)
-
PCN reaction
-
Rheumatic fever
-
Autoimmune thrombocytopenic purpura
-
Goodpasture syndrome
-
Grave's disease
Questão 21
Questão
Type III HSR - damaged tissues are innocent bystanders when a circulating (soluble antigen) immune complex becomes deposited in the tissues - true or false
Responda
- True
- False
Questão 22
Questão
When immune complexes (ICs) exceed disposal the net result is inflammation locally or systemically - true or false
Responda
- True
- False
Questão 23
Questão
All of the following are Type III HSR except
Responda
-
Serum sickness
-
Farmer's lung (Arthus reaction)
-
SLE
-
Post Streptococcal glomerulonephritis (PSGN)
-
None of the above
Questão 24
Questão
Lumpy bumpy pattern of nephritis is characteristic of PSGN - true or false
Responda
- True
- False
Questão 25
Questão
All of the following are true about Arthus reaction except?
Responda
-
Farmer's lung is an example of Arthus reaction
-
Arthus reaction is used in the skin testing of HSR III
-
Arthus reactions are visualized in the skin
-
none of the above
Questão 26
Questão
All of the following are true about delayed type IV HSR except?
Responda
-
Starts 49-72 hours after antigen exposure
-
T cell release cytokines that activate macrophages resulting in cell damage
-
B cells form antibodies that are delayed in their response hence called delayed HSR
-
Mediated by Th1 cells and CD8+ cytotoxic T cells
Questão 27
Questão
HSR IV is an inappropriate manifestation of DTH response that normally protects against intracellular bacterial and fungal infections - true or false
Responda
- True
- False
Questão 28
Questão
All of the following are examples of IV HSR except
Responda
-
PPD
-
Poison ivy dermatitis
-
contact dermatitis due to nickel exposure
-
Celiac disease
-
PSGN
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