439530
Descrição
Quiz por gina_evans0312, atualizado more than 1 year ago
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Criado por gina_evans0312
mais de 10 anos atrás
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Questão 1
Questão
Of known structures (60-80% of genes) how many are multidomain proteins?
Responda
-
40
-
50
-
60
-
30
Questão 2
Questão
Different combinations of domains are advantageous because they allow the organism to specialise
Responda
- True
- False
Questão 3
Questão
How can we recognize domains?
Responda
-
DNA sequencing
-
Amino acid sequencing
-
Structure
-
Topology (fold)
Questão 4
Questão
Why are DNA/amino acid sequencing of little use when investigating relationships between proteins?
Responda
-
As diversion occurs, sequence patterns are lost even as the fold remains the same
-
They can detect short evolutionary relationships only
-
The techniques for reading the sequences are unreliable
-
Identical sequences can give different aa sequences/folds
Questão 5
Questão
When investigating using structure, how do we identify domains?
Responda
-
Amino acid sequence
-
Domains have the same fold
-
The interaction of the protein with other proteins
Questão 6
Questão
There is a limited number of folds in nature (10^3-4)
Responda
- True
- False
Questão 7
Questão
Structural similarity occurs from what kind of evolution?
Responda
-
Divergent
-
Convergent
Questão 8
Questão
Sequence is more highly conserved than protein structure
Responda
- True
- False
Questão 9
Questão
Define convergent evolution
Responda
-
The independent evolution of similar features in different lineages
-
The carrying of a feature from a common ancestor into two lines, which allows the reconvergence of the two lines into a single species again
-
The dependent evolution of similar features in two species that interact/co-operate closely
Questão 10
Questão
How does the CATH system establish taxonomy?
Responda
-
Cut proteins into domains and use computor analysis to group domains
-
Uses structure based analysis
Questão 11
Questão
Which of the following classifications would be in the Class portion of the CATH system
Responda
-
Connectivity of fold
-
Barrel
-
Mostly alpha
Questão 12
Questão
Which of the following would be in the Architecture domain of the CATH system
Responda
-
Mostly beta
-
Both
-
Two layer sandwitch
-
Connectivity of fold
-
Barrel
Questão 13
Questão
Put the following in order of their use in the CATH system
A- Class
B- Sequence Superfamily
C- Homologous Superfamily
D-Architecture
E- Topology
Responda
-
A-D-E-C-B
-
B-A-C-E-D
-
D-E-A-B-C
Questão 14
Questão
There are 3 classes, 32 architectures and 820 topologies in the CATH system
Responda
- True
- False
Questão 15
Questão
The SCOP classifications, in descending order, are Class-Superfamily-Family-Fold-Species
Responda
- True
- False
Questão 16
Questão
What is the specification after Superfamiy in the Pfam system?
Responda
-
Fold
-
Architecture
-
Clade
Questão 17
Questão
All the systems agree in _% of cases
Responda
-
30-40
-
40-50
-
50-60
-
60-70
Questão 18
Questão
To be homologous, two proteins must have two of which of the following in common?
Responda
-
Structural Similarity
-
Sequence Similarity
-
Functional Simiarity
-
Species Similarity
-
Genus Similarity
Questão 19
Questão
What is the following describing- a protein contained in two different species with a similar function due to divergent evolution
Responda
-
Orthologues
-
Paralogues
Questão 20
Questão
What is the following describing- changes to a sequence following gene duplication leads to a variant copy with an additional (usually similar) function in the same species
Responda
-
Orthologues
-
Paralogues
Questão 21
Questão
Give the two defining features of orthologues
Responda
-
RMSD of >4
-
High SI
-
Low SI
-
SI may be high or low
Questão 22
Questão
NAD is a co-enzyme found in all living cells that accepts and donates electrons
Responda
- True
- False
Questão 23
Questão
NAD is made of three nucleotides and a phosphate group
Responda
- True
- False
Questão 24
Questão
Which of the following binds NAD when present in a protein?
Responda
-
A Rossman Fold
-
A Sherman Fold
-
A Fieldman Fold
Questão 25
Questão
The Rossman Fold has it's 6 beta sheets arranged in what order?
Responda
-
654123
-
123456
-
615243
Questão 26
Questão
In a Rossman fold, the crossover of the strands form the binding site
Responda
- True
- False
Questão 27
Questão
In lactate dehydrogenase, which terminal domain contains the Rossman fold?
Responda
-
C
-
N
Questão 28
Questão
What is the role of the C-terminal domain in dehydrogenases?
Responda
-
Enzyme specificity
-
Enzyme regulation
-
Enzyme catalytic activity
Questão 29
Questão
Lactate dehydrogenase catalyses lactate --> oxaloacetate
Responda
- True
- False
Questão 30
Questão
Malate dehydrogenase is structually identical to LADH, so why do they have different substrates?
Responda
-
An SI of 17%
-
They operate in cells where only one or the other is avalible
-
Lactate and malate are structurally identical, but have different components
Questão 31
Questão
How can we tell two proteins are not homologues?
Responda
-
They have a different function
-
They have a different S.I
-
They're found in different species
-
They're structurally different
Questão 32
Questão
What is the following descrbing- the existence of a shared ancestry between two structures (in this case proteins)
Responda
-
Homology
-
Divergent evolution
-
Convergent evolution
Questão 33
Questão
Alcohol dehydrogenase contains a Rossman fold
Responda
- True
- False
Questão 34
Questão
ADH and LDH have an RMSD of 2.2 & an S.I of 17%- what relationship do they share?
Responda
-
Orthologues
-
Paralogues
Questão 35
Questão
In the case of sequence diversity between proteins, surface residues change less than core/functional site residues
Responda
- True
- False
Questão 36
Questão
Where do residue insertions usually occur?
Responda
-
In the functional site
-
In loops connecting secondary structures
-
In alpha helices
Questão 37
Questão
The functional diversity of a domain superfamily depends on the fold
Responda
- True
- False
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