Supersecondary Structures & Energy Changes

Descrição

Structural Basis for Biological Function (Protein Folding) Quiz sobre Supersecondary Structures & Energy Changes, criado por gina_evans0312 em 19-12-2013.
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Quiz por gina_evans0312, atualizado more than 1 year ago
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Criado por gina_evans0312 mais de 10 anos atrás
475
1

Resumo de Recurso

Questão 1

Questão
Alpha helices are a helix-helix structure
Responda
  • True
  • False

Questão 2

Questão
Which of the following best describes an alpha helix?
Responda
  • Ridges are formed by side chains with troughs in between
  • Ridges are formed by the peptide bonds and the amino acid side chains form the troughs

Questão 3

Questão
Helix-helix packing can be shown by highlighting every _ residues?
Responda
  • 1st
  • 4th
  • 3rd
  • 2nd

Questão 4

Questão
Alpha helices must follow particular rules when packing together
Responda
  • True
  • False

Questão 5

Questão
Describe the ridges of the following proteins
Responda
  • i + 4
  • i + 2
  • i + 3

Questão 6

Questão
The angle between two packed helices depends on which type of ridges pack into which troughs.
Responda
  • True
  • False

Questão 7

Questão
The troughs of one alpha helix will be filled by the 'backbone' of another
Responda
  • True
  • False

Questão 8

Questão
Beta sheets twist slightly _ each other
Responda
  • Away from
  • Towards

Questão 9

Questão
The angle between two beta sheets is approx....?
Responda
  • 30 degrees
  • 60 degrees
  • 90 degrees

Questão 10

Questão
Where in the plane is each color (ignore green)
Responda
  • Yellow- above plane White- below plane
  • White- above plane Yellow- below plane
  • The amino acids will point in opposite directions

Questão 11

Questão
The strands of beta sheets are held together by backbone hydrogen bonding
Responda
  • True
  • False

Questão 12

Questão
The angle between sheets is determined by their...
Responda
  • Right handed twist
  • Left handed twist
  • Length
  • Amino acid side chains

Questão 13

Questão
How are the aa side chains arranged in beta sheets?
Responda
  • The amino acid residue side chains of one beta sheet pack between the spaces between side chains on the adjacent beta sheet
  • The amino acids on one beta sheet will have no residue where the other beta sheet has one (they're removed)
  • The amino acids with residues attached will alternate between beta sheets

Questão 14

Questão
When an alpha helix and a beta sheet pack together, the groove the beta sheet lies in tends to be made by amino acids how far apart?
Responda
  • 4n
  • 6n
  • 3n
  • 2n

Questão 15

Questão
Name three things that can be used in protein folding to encourage correct folding?
Responda
  • Non-native interactions (as long as they are reversible)
  • Pinching (isolates subdomains for folding)
  • The removal of a domain for folding, before it's re-addition

Questão 16

Questão
Negative Free Energy is less favorable
Responda
  • True
  • False

Questão 17

Questão
Concerning entropy- less order is more favorable
Responda
  • True
  • False

Questão 18

Questão
Which of the following is the equation for the free energy change of a folded protein
Responda
  • ΔG = ΔH - TΔS
  • ΔH = ΔG x TΔS
  • TΔS = ΔH + ΔG

Questão 19

Questão
Hydrogen bonds are the least common type of bond in proteins
Responda
  • True
  • False

Questão 20

Questão
What's the enthalpy change of a H bond formation?
Responda
  • -4 to -30 kJmol
  • -4 to -3 kJmol
  • -40 to -30 kJmol

Questão 21

Questão
A hydrophobic core in water is entropically favorable
Responda
  • True
  • False

Questão 22

Questão
Why is hydrophobic cores in water _favorable?
Responda
  • They make the water molecules more ordered, decreasing entropy
  • They make the water molecules less ordered, increasing entropy

Questão 23

Questão
Why do hydrophobic proteins fold?
Responda
  • Folded proteins have a reduced surface area, leading to a reduced number of organised water molecules, leading to a lower decrease of entropy
  • Folded proteins have a reduced surface area, leading to a reduced number of organised water molecules, leading to a lower increase of entropy

Questão 24

Questão
As water ordering decreases, entropy decreases
Responda
  • True
  • False

Questão 25

Questão
Why is energy needed to maintain the folding of a (hydrophobic) protein (i.e. from hydrogen bonds etc.)?
Responda
  • Because the unfolded state of the protein is more entropically favorable than the folded state
  • Because though the folded protein is more entropically favorable, it's folding decreases entropy, which is unfavorable
  • So energy must be produced to maintain the fold

Questão 26

Questão
Heating denatures a protein because it breaks the bonds required to offset the negative change in entropy caused by the protein folding i.e, it makes ΔH less negative
Responda
  • True
  • False

Questão 27

Questão
In protein folding, ΔH is negative, and -TΔS is positive
Responda
  • True
  • False

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