449488
Descrição
Quiz por gina_evans0312, atualizado more than 1 year ago
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Criado por gina_evans0312
quase 11 anos atrás
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Questão 1
Questão
Alpha helices are a helix-helix structure
Responda
- True
- False
Questão 2
Questão
Which of the following best describes an alpha helix?
Responda
-
Ridges are formed by side chains with troughs in between
-
Ridges are formed by the peptide bonds and the amino acid side chains form the troughs
Questão 3
Questão
Helix-helix packing can be shown by highlighting every _ residues?
Responda
-
1st
-
4th
-
3rd
-
2nd
Questão 4
Questão
Alpha helices must follow particular rules when packing together
Responda
- True
- False
Questão 5
Responda
-
i + 4
-
i + 2
-
i + 3
Questão 6
Questão
The angle between two packed helices depends on which type of ridges pack into which troughs.
Responda
- True
- False
Questão 7
Questão
The troughs of one alpha helix will be filled by the 'backbone' of another
Responda
- True
- False
Questão 8
Questão
Beta sheets twist slightly _ each other
Responda
-
Away from
-
Towards
Questão 9
Questão
The angle between two beta sheets is approx....?
Responda
-
30 degrees
-
60 degrees
-
90 degrees
Questão 10
Responda
-
Yellow- above plane White- below plane
-
White- above plane Yellow- below plane
-
The amino acids will point in opposite directions
Questão 11
Questão
The strands of beta sheets are held together by backbone hydrogen bonding
Responda
- True
- False
Questão 12
Questão
The angle between sheets is determined by their...
Responda
-
Right handed twist
-
Left handed twist
-
Length
-
Amino acid side chains
Questão 13
Questão
How are the aa side chains arranged in beta sheets?
Responda
-
The amino acid residue side chains of one beta sheet pack between the spaces between side chains on the adjacent beta sheet
-
The amino acids on one beta sheet will have no residue where the other beta sheet has one (they're removed)
-
The amino acids with residues attached will alternate between beta sheets
Questão 14
Questão
When an alpha helix and a beta sheet pack together, the groove the beta sheet lies in tends to be made by amino acids how far apart?
Responda
-
4n
-
6n
-
3n
-
2n
Questão 15
Questão
Name three things that can be used in protein folding to encourage correct folding?
Responda
-
Non-native interactions (as long as they are reversible)
-
Pinching (isolates subdomains for folding)
-
The removal of a domain for folding, before it's re-addition
Questão 16
Questão
Negative Free Energy is less favorable
Responda
- True
- False
Questão 17
Questão
Concerning entropy- less order is more favorable
Responda
- True
- False
Questão 18
Questão
Which of the following is the equation for the free energy change of a folded protein
Responda
-
ΔG = ΔH - TΔS
-
ΔH = ΔG x TΔS
-
TΔS = ΔH + ΔG
Questão 19
Questão
Hydrogen bonds are the least common type of bond in proteins
Responda
- True
- False
Questão 20
Questão
What's the enthalpy change of a H bond formation?
Responda
-
-4 to -30 kJmol
-
-4 to -3 kJmol
-
-40 to -30 kJmol
Questão 21
Questão
A hydrophobic core in water is entropically favorable
Responda
- True
- False
Questão 22
Questão
Why is hydrophobic cores in water _favorable?
Responda
-
They make the water molecules more ordered, decreasing entropy
-
They make the water molecules less ordered, increasing entropy
Questão 23
Questão
Why do hydrophobic proteins fold?
Responda
-
Folded proteins have a reduced surface area, leading to a reduced number of organised water molecules, leading to a lower decrease of entropy
-
Folded proteins have a reduced surface area, leading to a reduced number of organised water molecules, leading to a lower increase of entropy
Questão 24
Questão
As water ordering decreases, entropy decreases
Responda
- True
- False
Questão 25
Questão
Why is energy needed to maintain the folding of a (hydrophobic) protein (i.e. from hydrogen bonds etc.)?
Responda
-
Because the unfolded state of the protein is more entropically favorable than the folded state
-
Because though the folded protein is more entropically favorable, it's folding decreases entropy, which is unfavorable
-
So energy must be produced to maintain the fold
Questão 26
Questão
Heating denatures a protein because it breaks the bonds required to offset the negative change in entropy caused by the protein folding i.e, it makes ΔH less negative
Responda
- True
- False
Questão 27
Questão
In protein folding, ΔH is negative, and -TΔS is positive
Responda
- True
- False
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